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The effect of a single and a split dose of glibenclamide and glipizide on the diurnal levels of blood glucose and plasma insulin were compared in 15 insulin-independent diabetics. The patients were treated for two weeks with a) glibenclamide or glipizide 5 mg b.i.d., b) diet alone, c) glibenclamide or glipizide 7.5 mg o.d., and d) crossing over of c). The patients were on isocaloric diet and the diurnal levels of blood glucose and plasma insulin were determined after each period. As compared to the diet, the single morning dose of both drugs reduced the blood glucose values to the same extent (p < 0.001) without any effect on corresponding insulin-levels. The single morning dose was sufficient to provide adequate blood glucose control for up to 24-hours. There was no further benefit of the (even greater) split doses. In accordance with the augmented physiologic insulin release in the morning, a single morning dose of sulfonylureas may be the preferable dosage regimen in the treatment of elderly insulin-independent diabetics of moderate degree.
L Groop, and
K Harno
January 1973,
Acta diabetologica latina,
L Groop, and
K Harno
February 1982,
Scandinavian journal of clinical and laboratory investigation,
L Groop, and
K Harno
January 1979,
Current medical research and opinion,
L Groop, and
K Harno
December 1970,
Postgraduate medical journal,
L Groop, and
K Harno
January 1971,
Verhandlungen der Deutschen Gesellschaft fur Innere Medizin,
L Groop, and
K Harno
October 1972,
Mayo Clinic proceedings,
L Groop, and
K Harno
June 1978,
La Clinica terapeutica,
L Groop, and
K Harno
January 1985,
European journal of clinical pharmacology,
L Groop, and
K Harno
January 1974,
Minerva medica,
L Groop, and
K Harno
April 1970,
Diabetologia,
