-transparent.png){kind=logo}
In vitro incubation of Trypanosoma cruzi (Y strain) with 3-allyl-beta-lapachone was followed by: (1) growth inhibition of epimastigotes, (2) damage to cellular membranes, especially of the mitochondria, alterations in the chromatin structure and swelling of mitochondria, (3) increase in the respiratory rate, (4) increase in the rate of H2O2 generation by the epimastigotes, (5) increase of the rate of lipid peroxidation as detected by malonyldialdehyde formation, (6) decrease or total disappearance of trypomastigotes from mouse-infected blood. This drug might therefore be useful in preventing transmission of Chagas' disease during blood transfusion. It is not, however, active against infections in mice.
A M Gonçalves, and
M E Vasconcellos, and
R Docampo, and
F S Cruz, and
W de Souza, and
W Leon
January 2008,
Bioorganic & medicinal chemistry,
A M Gonçalves, and
M E Vasconcellos, and
R Docampo, and
F S Cruz, and
W de Souza, and
W Leon
May 2017,
MedChemComm,
A M Gonçalves, and
M E Vasconcellos, and
R Docampo, and
F S Cruz, and
W de Souza, and
W Leon
August 1975,
The Journal of protozoology,
A M Gonçalves, and
M E Vasconcellos, and
R Docampo, and
F S Cruz, and
W de Souza, and
W Leon
May 2010,
Bioorganic & medicinal chemistry,
A M Gonçalves, and
M E Vasconcellos, and
R Docampo, and
F S Cruz, and
W de Souza, and
W Leon
January 1992,
Memorias do Instituto Oswaldo Cruz,
A M Gonçalves, and
M E Vasconcellos, and
R Docampo, and
F S Cruz, and
W de Souza, and
W Leon
May 1979,
The Journal of protozoology,
A M Gonçalves, and
M E Vasconcellos, and
R Docampo, and
F S Cruz, and
W de Souza, and
W Leon
December 1972,
Annals of tropical medicine and parasitology,
A M Gonçalves, and
M E Vasconcellos, and
R Docampo, and
F S Cruz, and
W de Souza, and
W Leon
January 1986,
Arzneimittel-Forschung,
A M Gonçalves, and
M E Vasconcellos, and
R Docampo, and
F S Cruz, and
W de Souza, and
W Leon
June 1977,
Experimental parasitology,
A M Gonçalves, and
M E Vasconcellos, and
R Docampo, and
F S Cruz, and
W de Souza, and
W Leon
March 1978,
Acta tropica,
