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Fifty-one patients with Paget's disease were treated during 6 months with ethane-01 hydroxy-1, 1 diphosphonate (EHDP, etidronate) in doses of 5 mg/kg/day. The drug was most effective in relieving pain, at the same time diminishing the uptake of pagetic lesions on quantitative bone scans and lowering by almost 70% the abnormally high serum alkaline phosphatase levels and 24-hour hydroxyproline urinary levels. Histologically, the resorption surfaces and the number of osteoclasts per mm2 of bone tissue were significantly reduced. On follow-up, the improvement persisted for at least one year after treatment was discontinued. EHDP was well tolerated clinically and biologically, and on histological sections no accumulation of osteoid tissue due to impaired mineralization was seen. EHDP at the 5 mg/kg/day dose appears to be effective in the treatment of Paget's disease.
C Alexandre, and
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The Journal of endocrinology,
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June 1982,
La Nouvelle presse medicale,
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January 1974,
The Netherlands journal of medicine,
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June 1978,
Kaku igaku. The Japanese journal of nuclear medicine,
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October 1975,
Lancet (London, England),
C Alexandre, and
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October 1985,
Revista clinica espanola,
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April 1984,
Clinical orthopaedics and related research,
C Alexandre, and
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November 1975,
Revue du rhumatisme et des maladies osteo-articulaires,
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January 1981,
Metabolic bone disease & related research,
