-transparent.png){kind=logo}
The effect on exercise tolerance of nitroglycerin (NTG) ointment was studied by exercise test on bicycle ergometer in a selected group of patients with effort angina and angiographically proven critical coronary lesions. NTG ointment (15 mg) and placebo were administered in a double-blind cross-over randomized trial on two consecutive days; exercise test was carried out before the administration of NTG ointment and placebo, and repeated after one hour, 2 and 1/2 hours and 4 hours. Compared to control and placebo tests, NTG ointment produced a highly significant increase of duration of exercise and of total work load in all tests, as well as a significant decrease of maximal ST segment depression. After NTG ointment administration resting systolic blood pressure showed a significant decrease after one hour, 2 and 1/2 hours and 4 hours, resting heart rate a significant increase after 2 and 1/2 and 4 hours, and peak exercise heart rate a significant increase after 4 hours. Double product at rest was unaffected by NTG ointment, while at peak exercise it showed a significant increase only after 4 hours. Our data show that in patients with effort angina NTG ointment produces an important increase of exercise capacity which persists at least for 4 hours after the administration. Therefore NTG ointment seems to be of high value in the treatment of effort angina.
M Previtali, and
J A Salerno, and
C Falcone, and
R Lepore, and
M Chimienti, and
A Medici, and
L Angoli, and
P Bobba
November 1978,
American heart journal,
M Previtali, and
J A Salerno, and
C Falcone, and
R Lepore, and
M Chimienti, and
A Medici, and
L Angoli, and
P Bobba
January 1983,
European journal of clinical pharmacology,
M Previtali, and
J A Salerno, and
C Falcone, and
R Lepore, and
M Chimienti, and
A Medici, and
L Angoli, and
P Bobba
August 1974,
Circulation,
M Previtali, and
J A Salerno, and
C Falcone, and
R Lepore, and
M Chimienti, and
A Medici, and
L Angoli, and
P Bobba
April 1976,
Angiology,
M Previtali, and
J A Salerno, and
C Falcone, and
R Lepore, and
M Chimienti, and
A Medici, and
L Angoli, and
P Bobba
January 1978,
Giornale italiano di cardiologia,
M Previtali, and
J A Salerno, and
C Falcone, and
R Lepore, and
M Chimienti, and
A Medici, and
L Angoli, and
P Bobba
April 1982,
The Journal of the Association of Physicians of India,
M Previtali, and
J A Salerno, and
C Falcone, and
R Lepore, and
M Chimienti, and
A Medici, and
L Angoli, and
P Bobba
January 1989,
Cardiovascular drugs and therapy,
M Previtali, and
J A Salerno, and
C Falcone, and
R Lepore, and
M Chimienti, and
A Medici, and
L Angoli, and
P Bobba
September 1980,
La Nouvelle presse medicale,
M Previtali, and
J A Salerno, and
C Falcone, and
R Lepore, and
M Chimienti, and
A Medici, and
L Angoli, and
P Bobba
March 1982,
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine,
M Previtali, and
J A Salerno, and
C Falcone, and
R Lepore, and
M Chimienti, and
A Medici, and
L Angoli, and
P Bobba
March 1981,
Journal of cardiography,
