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Action of 6-hydroxydopamine on two parameters of motor learning. 1980

P Derevenco, and I Baciu, and N Stoica, and I Sovrea, and V Vitebski, and A Vaida, and V Zdrenghea

In rats injected in the cerebral ventricle with 250 micrograms of 6-hydroxydopamine a significant blockade of the improvement of swimming performance due to training occurs. The central injection of 6-OHDA leads to a lengthening of the total latency time (LT) of active conditioned reaction in shuttle box and of the LT of netative escape responses during learning, but not of the positive avoidance responses. 6-OHDA injected after the learing schedule (12 days) has no effect on the LT during relearning and extinction. Therefore a partial destruction of central monoaminergic, and especially of dopaminergic, neurons impairs particularly the acquisition but not the retention of the motor program.

UI MeSH Term Description Entries
D007276 Injections, Intraventricular Injections into the cerebral ventricles. Intraventricular Injections,Injection, Intraventricular,Intraventricular Injection
D007837 Latency Period, Psychological The period from about 5 to 7 years to adolescence when there is an apparent cessation of psychosexual development. Latency Period (Psychology),Latency Period, Psychology,Latency Periods (Psychology),Latency Periods, Psychological,Latency Periods, Psychology,Period, Latency (Psychology),Period, Psychological Latency,Period, Psychology Latency,Periods, Latency (Psychology),Periods, Psychological Latency,Periods, Psychology Latency,Psychological Latency Period,Psychological Latency Periods,Psychology Latency Period,Psychology Latency Periods
D007858 Learning Relatively permanent change in behavior that is the result of past experience or practice. The concept includes the acquisition of knowledge. Phenomenography
D010805 Physical Conditioning, Animal Diet modification and physical exercise to improve the ability of animals to perform physical activities. Animal Physical Conditioning,Animal Physical Conditionings,Conditioning, Animal Physical,Conditionings, Animal Physical,Physical Conditionings, Animal
D003213 Conditioning, Psychological Simple form of learning involving the formation, strengthening, or weakening of an association between a stimulus and a response. Conditioning, Psychology,Psychological Conditioning,Social Learning Theory,Social Learning Theories,Theory, Social Learning
D004924 Escape Reaction Innate response elicited by sensory stimuli associated with a threatening situation, or actual confrontation with an enemy. Flight Reaction,Escape Reactions,Flight Reactions,Reaction, Escape,Reaction, Flight,Reactions, Escape,Reactions, Flight
D006892 Hydroxydopamines Dopamines with a hydroxy group substituted in one or more positions. Hydroxydopamine
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D001362 Avoidance Learning A response to a cue that is instrumental in avoiding a noxious experience. Aversion Behavior,Aversion Learning,Aversive Behavior,Aversive Learning,Avoidance Behavior,Aversion Behaviors,Aversive Behaviors,Avoidance Behaviors,Behavior, Aversion,Behavior, Aversive,Behavior, Avoidance,Behaviors, Aversion,Behaviors, Aversive,Behaviors, Avoidance,Learning, Aversion,Learning, Aversive,Learning, Avoidance
D013564 Sympathetic Nervous System The thoracolumbar division of the autonomic nervous system. Sympathetic preganglionic fibers originate in neurons of the intermediolateral column of the spinal cord and project to the paravertebral and prevertebral ganglia, which in turn project to target organs. The sympathetic nervous system mediates the body's response to stressful situations, i.e., the fight or flight reactions. It often acts reciprocally to the parasympathetic system. Nervous System, Sympathetic,Nervous Systems, Sympathetic,Sympathetic Nervous Systems,System, Sympathetic Nervous,Systems, Sympathetic Nervous

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