-transparent.png){kind=logo}
Chloroquine forms complexes with polyanions as does the metachromatic dye pseudoisocyanine. This phenomenon can be used to show chloroquine binding to polyanions. It is shown spectrophotometrically that glycosaminoglycans form complexes with chloroquine more readily than with pseudoisocyanine. Moreover chloroquine abolishes fluorescence of glycosaminoglycan inclusion bodies in leucocytes of mucopolysaccharidosis patients. A woman of 34 suffering from mucopolysaccharidosis type I-S had such inclusion bodies in 19 out of 200 leucocytes examined before and in only two after a month of chloroquine treatment. In heparinized blood chloroquine induces clotting faster than does saline in control samples. This finding suggests inactivation of polyanions by chloroquine binding.
J Suschke, and
R Wilhelm, and
U Walther
January 1997,
Biochemistry and molecular biology international,
J Suschke, and
R Wilhelm, and
U Walther
February 1981,
Zhurnal mikrobiologii, epidemiologii i immunobiologii,
J Suschke, and
R Wilhelm, and
U Walther
April 1987,
Collagen and related research,
J Suschke, and
R Wilhelm, and
U Walther
December 1965,
Zentralblatt fur Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene. 1. Abt. Medizinisch-hygienische Bakteriologie, Virusforschung und Parasitologie. Originale,
J Suschke, and
R Wilhelm, and
U Walther
April 1964,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
J Suschke, and
R Wilhelm, and
U Walther
October 1970,
Hoppe-Seyler's Zeitschrift fur physiologische Chemie,
J Suschke, and
R Wilhelm, and
U Walther
September 1998,
Biopolymers,
J Suschke, and
R Wilhelm, and
U Walther
January 2002,
Arzneimittel-Forschung,
J Suschke, and
R Wilhelm, and
U Walther
January 1970,
Antimicrobial agents and chemotherapy,
J Suschke, and
R Wilhelm, and
U Walther
January 1972,
Journal of the Indian Medical Association,
