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A reported fluorometric method to determine tetracycline in biological material was modified to determine low levels of the antibiotics when using only small amounts of starting material. The method is applicable to tissue distribution studies in small experimental animals and also can be used for serial determinations in blood samples of these animals and for biopsy material. The tetracyclines are extracted in the presence of ethylenediaminetetraacetic acid, and the phosphate precipitation steps are omitted. This omission makes the procedures considerably less time consuming. The recoveries of the tetracyclines, oxytetracycline and doxycycline, are approximately 80-100%. The values obtained by this method were consistent with those from microbiological assays, and its reliability was shown further in a comparison with the fate of radioactive tetracycline.
C van den Bogert, and
A M Kroon
June 1972,
Biochemical medicine,
C van den Bogert, and
A M Kroon
November 1990,
Journal of forensic sciences,
C van den Bogert, and
A M Kroon
November 1972,
Analytical biochemistry,
C van den Bogert, and
A M Kroon
January 1975,
Advances in experimental medicine and biology,
C van den Bogert, and
A M Kroon
February 1970,
Journal of applied physiology,
C van den Bogert, and
A M Kroon
January 1969,
International archives of allergy and applied immunology,
C van den Bogert, and
A M Kroon
January 1971,
Laboratornoe delo,
C van den Bogert, and
A M Kroon
January 2016,
Talanta,
C van den Bogert, and
A M Kroon
April 1972,
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan,
C van den Bogert, and
A M Kroon
May 1971,
Pharmaceutisch weekblad,
