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The effects of (D-Met2,Pro5)-enkephalinamide--a superactive enkephalin analogue--on the preovulatory discharge of gonadotrophic hormones and on ovulation were investigated. Injection of the opioid (16 nmol) into a lateral cerebral ventricle of regularly cycling female rats immediately before the critical period on the day of proestrus resulted in a blockade of ovulation and in a concomitant depression of the preovulatory plasma luteinizing hormone and follicle-stimulating hormone levels. A smaller dose of the opioid (2 nmol) did not inhibit ovulation. The inhibition of the preovulatory gonadotrophic hormone discharge and the blockade of ovulation by the opioid were reversed by naloxone administration. Our data are consistent with the view that the endogenous opioid peptides may be involved in the physiological regulation of the central neural events which lead to ovulation in the rat.
K Köves, and
J Marton, and
J Molnár, and
B Halász
January 1990,
Acta physiologica Hungarica,
K Köves, and
J Marton, and
J Molnár, and
B Halász
October 1983,
Neuropeptides,
K Köves, and
J Marton, and
J Molnár, and
B Halász
March 1985,
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism,
K Köves, and
J Marton, and
J Molnár, and
B Halász
January 1990,
European journal of pharmacology,
K Köves, and
J Marton, and
J Molnár, and
B Halász
August 1981,
The Journal of pharmacy and pharmacology,
K Köves, and
J Marton, and
J Molnár, and
B Halász
April 1977,
FEBS letters,
K Köves, and
J Marton, and
J Molnár, and
B Halász
January 1983,
Life sciences,
K Köves, and
J Marton, and
J Molnár, and
B Halász
July 1982,
Life sciences,
K Köves, and
J Marton, and
J Molnár, and
B Halász
June 1977,
European journal of pharmacology,
K Köves, and
J Marton, and
J Molnár, and
B Halász
August 1997,
Drug design and discovery,
