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A patient with systemic mastocytosis, accompanied by gastric hypersecretion and duodenal ulcer, was treated with metiamide followed by daily cimetidine for 44 months. Treatment with cimetidine resulted in healing of the ulcer, without recurrence and marked amelioration of the cutaneous symptoms of mastocytosis. Complete suppression of basal gastric hypersecretion was documented after 33 months of treatment and cimetidine and Vitamin B12 absorption remained normal. Cimetidine reduced the patient's cutaneous response to intradermal histamine without affecting leucocyte histamine release. No cimetidine toxicity was observed. These results indicate that effective long-term control of histamine-induced gastric hypersecretion can be achieved with cimetidine. They suggest that some of the cutaneous symptoms of mastocytosis are mediated via histamine H2 receptors in the skin.
G J Johnson, and
S E Silvis, and
B Roitman, and
M Blumenthal, and
H S Gilbert
January 1992,
Dermatology (Basel, Switzerland),
G J Johnson, and
S E Silvis, and
B Roitman, and
M Blumenthal, and
H S Gilbert
September 1978,
The American journal of gastroenterology,
G J Johnson, and
S E Silvis, and
B Roitman, and
M Blumenthal, and
H S Gilbert
January 1993,
Alimentary pharmacology & therapeutics,
G J Johnson, and
S E Silvis, and
B Roitman, and
M Blumenthal, and
H S Gilbert
April 1977,
Lancet (London, England),
G J Johnson, and
S E Silvis, and
B Roitman, and
M Blumenthal, and
H S Gilbert
January 1982,
Medicina clinica,
G J Johnson, and
S E Silvis, and
B Roitman, and
M Blumenthal, and
H S Gilbert
May 1984,
Clinics in gastroenterology,
G J Johnson, and
S E Silvis, and
B Roitman, and
M Blumenthal, and
H S Gilbert
June 1991,
The Nursing clinics of North America,
G J Johnson, and
S E Silvis, and
B Roitman, and
M Blumenthal, and
H S Gilbert
July 1988,
Bailliere's clinical gastroenterology,
G J Johnson, and
S E Silvis, and
B Roitman, and
M Blumenthal, and
H S Gilbert
December 1974,
American family physician,
G J Johnson, and
S E Silvis, and
B Roitman, and
M Blumenthal, and
H S Gilbert
January 1978,
Advances in internal medicine,
