-transparent.png){kind=logo}
1. The pharmacological actions of a new short acting loop diuretic were investigated in nine healthy male subjects and compared with those of frusemide and bumetanide. Subjects received 6 mg piretanide/day, 40 mg frusemide/day or 1 mg bumetanide/day for a period of 1 week. 2. Comparison of effects following the first dose administered showed that 6 mg piretanide is of similar potency to 40 mg frusemide in terms of diuresis, natriuresis and kaliuresis but is less potent than 1 mg bumetanide. 3. All three diuretics caused a decrease in urate excretion and a rise in serum uric acid. 4. Piretanide was well tolerated. Further investigation is required to ascertain what clinical advantage it offers over frusemide and bumetanide.
C J Roberts, and
M Homeida, and
F Roberts, and
W Bogie
April 1981,
Neuropharmacology,
C J Roberts, and
M Homeida, and
F Roberts, and
W Bogie
January 1981,
Scandinavian audiology. Supplementum,
C J Roberts, and
M Homeida, and
F Roberts, and
W Bogie
September 1982,
Journal of veterinary pharmacology and therapeutics,
C J Roberts, and
M Homeida, and
F Roberts, and
W Bogie
September 1983,
Clinical pharmacology and therapeutics,
C J Roberts, and
M Homeida, and
F Roberts, and
W Bogie
March 1979,
Clinical pharmacology and therapeutics,
C J Roberts, and
M Homeida, and
F Roberts, and
W Bogie
August 1988,
The American journal of the medical sciences,
C J Roberts, and
M Homeida, and
F Roberts, and
W Bogie
January 1979,
Nephron,
C J Roberts, and
M Homeida, and
F Roberts, and
W Bogie
November 1984,
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde,
C J Roberts, and
M Homeida, and
F Roberts, and
W Bogie
September 1974,
Biomedicine / [publiee pour l'A.A.I.C.I.G.],
C J Roberts, and
M Homeida, and
F Roberts, and
W Bogie
January 1980,
Minerva nefrologica,
