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Aminoacyl derivatives of "bridged" nucleosides: chemical synthesis and substrate activity of 2'(3')-O-(N-acetyl)-L-leucyl-2''(3'')-O-L-phenylalanyl-(1,2-diadenosin-N6-yl)ethane, a spacer probe for ribosomal peptidyltransferase. 1978

C D Li, and P Bhuta, and J Zemlicka

UI MeSH Term Description Entries
D007700 Kinetics The rate dynamics in chemical or physical systems.
D008722 Methods A series of steps taken in order to conduct research. Techniques,Methodological Studies,Methodological Study,Procedures,Studies, Methodological,Study, Methodological,Method,Procedure,Technique
D008968 Molecular Conformation The characteristic three-dimensional shape of a molecule. Molecular Configuration,3D Molecular Structure,Configuration, Molecular,Molecular Structure, Three Dimensional,Three Dimensional Molecular Structure,3D Molecular Structures,Configurations, Molecular,Conformation, Molecular,Conformations, Molecular,Molecular Configurations,Molecular Conformations,Molecular Structure, 3D,Molecular Structures, 3D,Structure, 3D Molecular,Structures, 3D Molecular
D010458 Peptidyl Transferases Acyltransferases that use AMINO ACYL TRNA as the amino acid donor in formation of a peptide bond. There are ribosomal and non-ribosomal peptidyltransferases. Peptidyl Transferase,Peptidyl Translocase,Peptidyl Translocases,Peptidyltransferase,Transpeptidase,Transpeptidases,Peptidyltransferases,Transferase, Peptidyl,Transferases, Peptidyl,Translocase, Peptidyl,Translocases, Peptidyl
D004151 Dipeptides Peptides composed of two amino acid units. Dipeptide
D000217 Acyltransferases Enzymes from the transferase class that catalyze the transfer of acyl groups from donor to acceptor, forming either esters or amides. (From Enzyme Nomenclature 1992) EC 2.3. Acyltransferase
D000241 Adenosine A nucleoside that is composed of ADENINE and D-RIBOSE. Adenosine or adenosine derivatives play many important biological roles in addition to being components of DNA and RNA. Adenosine itself is a neurotransmitter. Adenocard,Adenoscan
D012270 Ribosomes Multicomponent ribonucleoprotein structures found in the CYTOPLASM of all cells, and in MITOCHONDRIA, and PLASTIDS. They function in PROTEIN BIOSYNTHESIS via GENETIC TRANSLATION. Ribosome
D014176 Protein Biosynthesis The biosynthesis of PEPTIDES and PROTEINS on RIBOSOMES, directed by MESSENGER RNA, via TRANSFER RNA that is charged with standard proteinogenic AMINO ACIDS. Genetic Translation,Peptide Biosynthesis, Ribosomal,Protein Translation,Translation, Genetic,Protein Biosynthesis, Ribosomal,Protein Synthesis, Ribosomal,Ribosomal Peptide Biosynthesis,mRNA Translation,Biosynthesis, Protein,Biosynthesis, Ribosomal Peptide,Biosynthesis, Ribosomal Protein,Genetic Translations,Ribosomal Protein Biosynthesis,Ribosomal Protein Synthesis,Synthesis, Ribosomal Protein,Translation, Protein,Translation, mRNA,mRNA Translations

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C D Li, and P Bhuta, and J Zemlicka
Simple models of nucleic acid interactions 2. Aminoacyl derivatives of "bridged" nucleosides: Synthesis of 2'(3')-O-L-phenylalanyl- and 2'(3')-O-L-leucyl-1,2-di(adenosin-N6-yl)ethane.
February 1977, The Journal of organic chemistry,
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Inhibition of ribosomal peptidyltransferase with 2'(3')-O-acetyl-2 inches(3 inches)-O-glycyl-1,2-di(adenosin-N6-yl)ethane and -1,4-di(adenosin-N6-yl)butane. Effect of alkyl chain length.
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Inhibition of ribosomal peptidyltransferase with cytidyl-3' leads to 5'-[2'(3')-O-L-phenylalanyl]-L-adenosine.
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