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Granulocyte mobilization into skin abrasions in human volunteers was significantly inhibited by acute alcohol intoxication (45,-800 cells in 8 hr versus 353,000 in normal controls). Alcohol applied locally did not inhibit granulocyte delivery, and protection of the abrasion against heat loss did not reduce the inhibited delivery in intoxicated volunteers. Intoxication inhibited granulocyte adherence and local mobilization in parallel. Alcohol administration to rabbits shifted granulocytes from marginal to circulating pool in a manner similar to epinephrine. Mobilization of bone marrow granulocytes by glucocorticoid or endotoxin administration was not inhibited by intoxication, nor did it prevent the endotoxin-induced shift of granulocytes from circulating to marginal pool.
S J Gluckman, and
R R MacGregor
January 1979,
British journal of clinical pharmacology,
S J Gluckman, and
R R MacGregor
January 1961,
Archives of neurology,
S J Gluckman, and
R R MacGregor
December 1976,
Polski tygodnik lekarski (Warsaw, Poland : 1960),
S J Gluckman, and
R R MacGregor
January 1960,
Transactions of the American Neurological Association,
S J Gluckman, and
R R MacGregor
July 1985,
Clinical pharmacology and therapeutics,
S J Gluckman, and
R R MacGregor
July 1993,
JAMA,
S J Gluckman, and
R R MacGregor
July 1986,
L'union medicale du Canada,
S J Gluckman, and
R R MacGregor
November 1978,
Therapie der Gegenwart,
S J Gluckman, and
R R MacGregor
December 2008,
European journal of internal medicine,
S J Gluckman, and
R R MacGregor
May 1946,
Schweizerische medizinische Wochenschrift,
