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The interest in the measurement of human sex steroid binding plasma protein (h-SBP) is now increasing since it allows the estimation of the free fraction of circulating hormones in plasma. Up to this date, this protein could only be determined by measuring the total binding capacity of serum for dihydrotestosterone (DHT). The purpose of the present work was to purify the protein, to prepare a rabbit monospecific antiserum and to develop an immunoelectrophoretic assay of h-SBP. The immunological assay is specific, accurate and sensitive. A good correlation with the radioligand assay was found. The h-SBP levels obtained by immunoelectrophoretic assay of different serum samples were 5.3 +/- 1.4 (SEM) mg/L in normal men and 13.4 +/- 2.6 (SEM) mg/L in normal women.
M Egloff, and
R Vranckx, and
J Tardivel-Lacombe, and
H Degrelle
January 1979,
Annales d'immunologie,
M Egloff, and
R Vranckx, and
J Tardivel-Lacombe, and
H Degrelle
July 1979,
Journal of steroid biochemistry,
M Egloff, and
R Vranckx, and
J Tardivel-Lacombe, and
H Degrelle
July 1987,
Clinica chimica acta; international journal of clinical chemistry,
M Egloff, and
R Vranckx, and
J Tardivel-Lacombe, and
H Degrelle
May 1986,
Biochemistry,
M Egloff, and
R Vranckx, and
J Tardivel-Lacombe, and
H Degrelle
July 1987,
FEBS letters,
M Egloff, and
R Vranckx, and
J Tardivel-Lacombe, and
H Degrelle
January 1970,
Acta endocrinologica. Supplementum,
M Egloff, and
R Vranckx, and
J Tardivel-Lacombe, and
H Degrelle
December 1994,
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M Egloff, and
R Vranckx, and
J Tardivel-Lacombe, and
H Degrelle
October 1988,
Steroids,
M Egloff, and
R Vranckx, and
J Tardivel-Lacombe, and
H Degrelle
January 1980,
Archives of biochemistry and biophysics,
M Egloff, and
R Vranckx, and
J Tardivel-Lacombe, and
H Degrelle
January 1981,
Journal of biochemistry,
