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Three patients were studied in whom brief contact of the skin with water at any temperature evoked intense itching without visible changes in the skin. The patients were otherwise apparently healthy, and this chronic and disabling disorder tended to attract a "psychogenic" label. Pharmacological studies showed that the condition was associated with local release of acetyl choline in the skin, mast-cell degranulation, and raised blood histamine concentrations. It responded well to antihistamines in two of the three patients. Aquagenic pruritus is probably common, but it is generally unrecognised and may be misdiagnosed. Antihistamines may induce a good therapeutic response.
M W Greaves, and
A K Black, and
R A Eady, and
A Coutts
July 1985,
Journal of the American Academy of Dermatology,
M W Greaves, and
A K Black, and
R A Eady, and
A Coutts
January 1999,
Annales de dermatologie et de venereologie,
M W Greaves, and
A K Black, and
R A Eady, and
A Coutts
June 1990,
Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete,
M W Greaves, and
A K Black, and
R A Eady, and
A Coutts
December 1995,
Seminars in dermatology,
M W Greaves, and
A K Black, and
R A Eady, and
A Coutts
December 1988,
Seminars in dermatology,
M W Greaves, and
A K Black, and
R A Eady, and
A Coutts
January 1984,
Dermatologische Monatschrift,
M W Greaves, and
A K Black, and
R A Eady, and
A Coutts
May 2008,
British journal of hospital medicine (London, England : 2005),
M W Greaves, and
A K Black, and
R A Eady, and
A Coutts
June 1989,
Journal of the American Academy of Dermatology,
M W Greaves, and
A K Black, and
R A Eady, and
A Coutts
September 1990,
Allergie et immunologie,
