Biomaterial Database

Free fatty acid turnover and oxidation after burn shock in guinea pigs. 1981

K M Robinson, and H I Miller

We have previously shown a rapid decrease in plasma free fatty acid (FFA) concentration and turnover rate immediately after extensive full-skin-thickness burn in a guinea pig model. In the present study the relationship between plasma FFA turnover rate and oxidation after burn was investigated, since the amount of plasma FFA oxidized is determined by the turnover rate and the percent of turnover that is oxidized. Using the constant infusion of 14C-palmitate, we examined the plasma FFA concentration and turnover rate, plasma FFA contribution to carbon dioxide production, percent of plasma FFA turnover that is rapidly oxidized to carbon dioxide, oxygen consumption, carbon dioxide production, and respiratory quotient. We found that in some cases, but not all, plasma FFA concentration and turnover rate were decreased 1-6 hours postburn. Both in the presence or absence of decreased FFA turnover rate, the percent of FFA turnover that was immediately oxidized to carbon dioxide was unchanged. After burn shock, the rate of oxidation of FFA appears to be controlled by the rate of FFA delivery to the tissues.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D010084	Oxidation-Reduction	A chemical reaction in which an electron is transferred from one molecule to another. The electron-donating molecule is the reducing agent or reductant; the electron-accepting molecule is the oxidizing agent or oxidant. Reducing and oxidizing agents function as conjugate reductant-oxidant pairs or redox pairs (Lehninger, Principles of Biochemistry, 1982, p471).	Redox,Oxidation Reduction
D001810	Blood Volume	Volume of circulating BLOOD. It is the sum of the PLASMA VOLUME and ERYTHROCYTE VOLUME.	Blood Volumes,Volume, Blood,Volumes, Blood
D002056	Burns	Injuries to tissues caused by contact with heat, steam, chemicals (BURNS, CHEMICAL), electricity (BURNS, ELECTRIC), or the like.	Burn
D002245	Carbon Dioxide	A colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals.	Carbonic Anhydride,Anhydride, Carbonic,Dioxide, Carbon
D005230	Fatty Acids, Nonesterified	FATTY ACIDS found in the plasma that are complexed with SERUM ALBUMIN for transport. These fatty acids are not in glycerol ester form.	Fatty Acids, Free,Free Fatty Acid,Free Fatty Acids,NEFA,Acid, Free Fatty,Acids, Free Fatty,Acids, Nonesterified Fatty,Fatty Acid, Free,Nonesterified Fatty Acids
D006168	Guinea Pigs	A common name used for the genus Cavia. The most common species is Cavia porcellus which is the domesticated guinea pig used for pets and biomedical research.	Cavia,Cavia porcellus,Guinea Pig,Pig, Guinea,Pigs, Guinea
D000273	Adipose Tissue	Specialized connective tissue composed of fat cells (ADIPOCYTES). It is the site of stored FATS, usually in the form of TRIGLYCERIDES. In mammals, there are two types of adipose tissue, the WHITE FAT and the BROWN FAT. Their relative distributions vary in different species with most adipose tissue being white.	Fatty Tissue,Body Fat,Fat Pad,Fat Pads,Pad, Fat,Pads, Fat,Tissue, Adipose,Tissue, Fatty
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D012774	Shock, Traumatic	Shock produced as a result of trauma.	Traumatic Shock