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Immunoglobulin (Ig) synthesis by immature B lymphocytes from human foetal liver and cord blood has been investigated. Seven out of fifteen preparations of foetal liver cells and eight out of eleven cord bloods synthesized Ig detectable by biosynthetic labelling. All cultures of foetal lymphocytes with detectable Ig synthesis secreted free light chain. Two of these cases also synthesized free mu heavy chain. Cord blood lymphocyte synthesis patterns were variable ranging from free light chain as the only secreted Ig product to balanced synthesis of heavy and light chains. No cord blood cultures synthesized detectable free mu chains. Free Ig-light-chain synthesis appears to be associated with normal immature B lymphocytes and the results are discussed in relation to the B-cell differentiation pathway.
A C Hannam-Harris, and
J L Smith
November 1978,
Clinical and experimental immunology,
A C Hannam-Harris, and
J L Smith
October 1979,
Experientia,
A C Hannam-Harris, and
J L Smith
June 1971,
Immunology,
A C Hannam-Harris, and
J L Smith
February 1978,
Clinical and experimental immunology,
A C Hannam-Harris, and
J L Smith
September 1986,
The Journal of clinical investigation,
A C Hannam-Harris, and
J L Smith
March 2011,
TheScientificWorldJournal,
A C Hannam-Harris, and
J L Smith
May 1971,
Experimental cell research,
A C Hannam-Harris, and
J L Smith
December 1981,
Immunology letters,
A C Hannam-Harris, and
J L Smith
July 1982,
Immunology letters,
A C Hannam-Harris, and
J L Smith
January 2006,
Journal of immunoassay & immunochemistry,
