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Secondary thyroid function tests were compared in 41 mildly thyrotoxic and 36 euthyroid patients with an elevated free thyroxine index (FT4I). A serum TSH measurement 20 minutes after intravenous TRH (delta TSH) most reliably separates these two groups. A significant delta TSH response (greater than 0.5 microU/ml) is also helpful in excluding clinical thyrotoxicosis in patients with nodular goitre. The free T3 index was normal in one-third of mildly thyrotoxic patients and in all euthyroid patients with a falsely elevated FT4I. Blunted delta TSH responses to TRH in elderly New Zealand women were associated with nodular goitre or occult thyroid nodularity revealed only by thyroid scan. The reduced TRH responses are more likely due to partial thyroid autonomy than reduced synthetic capacity of thyrotrophs in old age.
M S Croxson, and
T M Wilson, and
G H Ballantyne
December 1984,
Scandinavian journal of clinical and laboratory investigation,
M S Croxson, and
T M Wilson, and
G H Ballantyne
January 1979,
Klinicheskaia meditsina,
M S Croxson, and
T M Wilson, and
G H Ballantyne
June 1978,
Archives of internal medicine,
M S Croxson, and
T M Wilson, and
G H Ballantyne
February 1984,
Polski tygodnik lekarski (Warsaw, Poland : 1960),
M S Croxson, and
T M Wilson, and
G H Ballantyne
March 1979,
Archives of internal medicine,
M S Croxson, and
T M Wilson, and
G H Ballantyne
October 1969,
Horumon to rinsho. Clinical endocrinology,
M S Croxson, and
T M Wilson, and
G H Ballantyne
January 2021,
Indian journal of endocrinology and metabolism,
M S Croxson, and
T M Wilson, and
G H Ballantyne
May 1963,
Zdravookhranenie Belorussii,
M S Croxson, and
T M Wilson, and
G H Ballantyne
April 1985,
Postgraduate medical journal,
M S Croxson, and
T M Wilson, and
G H Ballantyne
July 1980,
Vestnik khirurgii imeni I. I. Grekova,
