BIOMAT Database Logo BIOMAT Database Logo

Alterations in circulating thyroid hormones and thyroxine binding globulin in chronic alcoholism. 1981

J Geurts, and N Demeester-Mirkine, and D Glinoer, and T Prigogine, and M Fernandez-Deville, and J Corvilain

The present study concerns eighteen chronic alcoholics with minimal liver damage. A significant reduction in total serum T4 with an accompanying drop in circulating TBG was observed in these otherwise euthyroid patients. During alcohol withdrawal, we observed a rapid increase in T4 and TBG into the normal range. We suggest that the fall in the level of circulating thyroxine-binding globulin is related to a defect in its synthesis or secretion by the liver due to ethanol consumption. Caution is recommended in the interpretation of thyroid function tests in chronic alcoholics.

UI MeSH Term Description Entries
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D000437 Alcoholism A primary, chronic disease with genetic, psychosocial, and environmental factors influencing its development and manifestations. The disease is often progressive and fatal. It is characterized by impaired control over drinking, preoccupation with the drug alcohol, use of alcohol despite adverse consequences, and distortions in thinking, most notably denial. Each of these symptoms may be continuous or periodic. (Morse & Flavin for the Joint Commission of the National Council on Alcoholism and Drug Dependence and the American Society of Addiction Medicine to Study the Definition and Criteria for the Diagnosis of Alcoholism: in JAMA 1992;268:1012-4) Alcohol Abuse,Alcoholic Intoxication, Chronic,Ethanol Abuse,Alcohol Addiction,Alcohol Dependence,Alcohol Use Disorder,Abuse, Alcohol,Abuse, Ethanol,Addiction, Alcohol,Alcohol Use Disorders,Chronic Alcoholic Intoxication,Dependence, Alcohol,Intoxication, Chronic Alcoholic,Use Disorders, Alcohol
D013960 Thyroid Function Tests Blood tests used to evaluate the functioning of the thyroid gland. Jostel's TSH Index,Jostel's Thyrotropin Index,Protein-Bound Iodine Test,SPINA-GD,SPINA-GT,Secretory Capacity of the Thyroid Gland,Sum Activity of Peripheral Deiodinases,Thyrotroph Thyroid Hormone Sensitivity Index,Thyroid Gland Function Tests,Function Test, Thyroid,Iodine Test, Protein-Bound,Jostel TSH Index,Jostel Thyrotropin Index,Jostel's TSH Indices,Jostels TSH Index,Jostels Thyrotropin Index,Protein Bound Iodine Test,Protein-Bound Iodine Tests,TSH Index, Jostel's,Test, Protein-Bound Iodine,Test, Thyroid Function,Thyroid Function Test,Thyrotropin Index, Jostel's
D013974 Thyroxine The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism. L-Thyroxine,Levothyroxine,T4 Thyroid Hormone,3,5,3',5'-Tetraiodothyronine,Berlthyrox,Dexnon,Eferox,Eltroxin,Eltroxine,Euthyrox,Eutirox,L-3,5,3',5'-Tetraiodothyronine,L-Thyrox,L-Thyroxin Henning,L-Thyroxin beta,L-Thyroxine Roche,Levo-T,Levothroid,Levothyroid,Levothyroxin Deladande,Levothyroxin Delalande,Levothyroxine Sodium,Levoxine,Levoxyl,Lévothyrox,Novothyral,Novothyrox,O-(4-Hydroxy-3,5-diiodophenyl) 3,5-diiodo-L-tyrosine,O-(4-Hydroxy-3,5-diiodophenyl)-3,5-diiodotyrosine,Oroxine,Sodium Levothyroxine,Synthroid,Synthrox,Thevier,Thyrax,Thyroxin,Tiroidine,Tiroxina Leo,Unithroid,L Thyrox,L Thyroxin Henning,L Thyroxin beta,L Thyroxine,L Thyroxine Roche,Levo T,Thyroid Hormone, T4
D013975 Thyroxine-Binding Proteins Blood proteins that bind to THYROID HORMONES such as THYROXINE and transport them throughout the circulatory system. Thyroxine Transport Protein,Thyroxine-Binding Protein,Thyroxine Binding Protein,Thyroxine Binding Proteins
D014284 Triiodothyronine A T3 thyroid hormone normally synthesized and secreted by the thyroid gland in much smaller quantities than thyroxine (T4). Most T3 is derived from peripheral monodeiodination of T4 at the 5' position of the outer ring of the iodothyronine nucleus. The hormone finally delivered and used by the tissues is mainly T3. Liothyronine,T3 Thyroid Hormone,3,3',5-Triiodothyronine,Cytomel,Liothyronine Sodium,Thyroid Hormone, T3

Related Publications

J Geurts, and N Demeester-Mirkine, and D Glinoer, and T Prigogine, and M Fernandez-Deville, and J Corvilain
Alterations in circulating thyroid hormones and thyroxine-binding globulin levels during diabetic ketoacidosis.
January 1980, Journal of endocrinological investigation,
J Geurts, and N Demeester-Mirkine, and D Glinoer, and T Prigogine, and M Fernandez-Deville, and J Corvilain
Alterations in serum thyroid hormones and thyroxine-binding globulin in patients with nephrosis.
January 1978, The Journal of clinical endocrinology and metabolism,
J Geurts, and N Demeester-Mirkine, and D Glinoer, and T Prigogine, and M Fernandez-Deville, and J Corvilain
Thyroxine-binding globulin and thyroid hormones after resection of hepatocellular carcinoma.
July 1997, The American journal of gastroenterology,
J Geurts, and N Demeester-Mirkine, and D Glinoer, and T Prigogine, and M Fernandez-Deville, and J Corvilain
Binding of thyroid hormones and their analogues to thyroxine-binding globulin in human serum.
November 1976, The Journal of biological chemistry,
J Geurts, and N Demeester-Mirkine, and D Glinoer, and T Prigogine, and M Fernandez-Deville, and J Corvilain
Serum thyroid hormones, thyrotropin and thyroxine binding globulin during prolonged strength training.
January 1988, European journal of applied physiology and occupational physiology,
J Geurts, and N Demeester-Mirkine, and D Glinoer, and T Prigogine, and M Fernandez-Deville, and J Corvilain
The influence of carbamazepine on thyroid hormones and thyroxine binding globulin in hypothyroid patients substituted with thyroxine.
September 1981, Clinical endocrinology,
J Geurts, and N Demeester-Mirkine, and D Glinoer, and T Prigogine, and M Fernandez-Deville, and J Corvilain
Thyroxine-binding globulin deficiency in early childhood. Postnatal changes in serum concentrations of thyroid hormones and thyroid hormone-binding proteins.
March 1981, Acta paediatrica Scandinavica,
J Geurts, and N Demeester-Mirkine, and D Glinoer, and T Prigogine, and M Fernandez-Deville, and J Corvilain
[Thyroxine binding globulin deficiency excluding thyroid pathology].
May 1984, Presse medicale (Paris, France : 1983),
J Geurts, and N Demeester-Mirkine, and D Glinoer, and T Prigogine, and M Fernandez-Deville, and J Corvilain
Ectopic thyroid gland and thyroxine-binding globulin excess.
September 1986, Acta paediatrica Scandinavica,
J Geurts, and N Demeester-Mirkine, and D Glinoer, and T Prigogine, and M Fernandez-Deville, and J Corvilain
Thyroid function tests in thyroxine-binding globulin deficiency.
November 1979, Annals of clinical biochemistry,
Copied contents to your clipboard!