Biomaterial Database

[Modification of the antigenicity of the serum thymic factor (thymulin) by zinc]. 1981

J M Pleau, and M Dardenne, and J F Bach

We have previously reported that the serum thymic factor (FTS) exists under two forms, one deprived of zinc, biologically inactive and another one containing zinc, biologically active for which we have proposed the name of thymulin (FTS-Zn). A new iodinated tracer (125I FTS-Zn) has been prepared by fixing zinc on synthetic FTS. This tracer is recognized by a Rabbit anti-FTS antiserum at a 1/20,000 dilution. Normal Mouse sera displace the binding of FTS-Zn to the antiserum (40-60% inhibition) whereas thymectomized mouse sera have no effect. These results should allow the establishment of a simple radioimmunoassay for thymulin (FTS-Zn) present in biological fluids.

UI	MeSH Term	Description	Entries
D011817	Rabbits	A burrowing plant-eating mammal with hind limbs that are longer than its fore limbs. It belongs to the family Leporidae of the order Lagomorpha, and in contrast to hares, possesses 22 instead of 24 pairs of chromosomes.	Belgian Hare,New Zealand Rabbit,New Zealand Rabbits,New Zealand White Rabbit,Rabbit,Rabbit, Domestic,Chinchilla Rabbits,NZW Rabbits,New Zealand White Rabbits,Oryctolagus cuniculus,Chinchilla Rabbit,Domestic Rabbit,Domestic Rabbits,Hare, Belgian,NZW Rabbit,Rabbit, Chinchilla,Rabbit, NZW,Rabbit, New Zealand,Rabbits, Chinchilla,Rabbits, Domestic,Rabbits, NZW,Rabbits, New Zealand,Zealand Rabbit, New,Zealand Rabbits, New,cuniculus, Oryctolagus
D002417	Cattle	Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.	Beef Cow,Bos grunniens,Bos indicus,Bos indicus Cattle,Bos taurus,Cow,Cow, Domestic,Dairy Cow,Holstein Cow,Indicine Cattle,Taurine Cattle,Taurus Cattle,Yak,Zebu,Beef Cows,Bos indicus Cattles,Cattle, Bos indicus,Cattle, Indicine,Cattle, Taurine,Cattle, Taurus,Cattles, Bos indicus,Cattles, Indicine,Cattles, Taurine,Cattles, Taurus,Cow, Beef,Cow, Dairy,Cow, Holstein,Cows,Dairy Cows,Domestic Cow,Domestic Cows,Indicine Cattles,Taurine Cattles,Taurus Cattles,Yaks,Zebus
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D000941	Antigens	Substances that are recognized by the immune system and induce an immune reaction.	Antigen
D013934	Thymectomy	Surgical removal of the thymus gland. (Dorland, 28th ed)	Thymectomies
D013935	Thymic Factor, Circulating	A thymus-dependent nonapeptide found in normal blood. Stimulates the formation of E rosettes and is believed to be involved in T-cell differentiation.	Facteur Thymique Serique,Serum Thymic Factor,Circulating Factor, Thymic,Factor, Thymic Circulating,Nonathymulin,Thymic Serum Factor,Thymulin,Thymuline,Circulating Thymic Factor,Factor, Circulating Thymic,Factor, Serum Thymic,Factor, Thymic Serum,Serique, Facteur Thymique,Serum Factor, Thymic,Thymic Circulating Factor,Thymic Factor, Serum,Thymique Serique, Facteur
D013951	Thymus Hormones	Humoral factors secreted by the thymus gland. They participate in the development of the lymphoid system and the maturation of the cellular immune response.	Thymic Hormones,Hormones, Thymic,Hormones, Thymus
D015032	Zinc	A metallic element of atomic number 30 and atomic weight 65.38. It is a necessary trace element in the diet, forming an essential part of many enzymes, and playing an important role in protein synthesis and in cell division. Zinc deficiency is associated with ANEMIA, short stature, HYPOGONADISM, impaired WOUND HEALING, and geophagia. It is known by the symbol Zn.
D051379	Mice	The common name for the genus Mus.	Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus