-transparent.png){kind=logo}
Selected inbred strains of mice were examined for susceptibility to peritoneal infections with Encephalitozoon cuniculi. Marked differences in susceptibility and resistance among mouse strains were not controlled by loci within the mouse major histocompatibility (H-2) complex, but resistance in BALB/c mice was influenced by a dominant gene(s) outside the H-2 complex. The lethality of peritoneal infections in hypothymic nude mice suggested that resistance to encephalitozoonosis is dependent on thymus-derived lymphocytes. Peritoneal infection with E. cuniculi was associated with slightly enhanced proliferative spleen cell responses to mitogens in BALB/c mice and significantly depressed responses in C57Bl/6 mice. Infection in BALB/c mice was accompanied by normal antibody responses to sheep erythrocyte immunogens, but C57Bl/6 mice had depressed antibody responses. The results indicate that the immune system plays a major role in determining the course of peritoneal infections with E. cuniculi and that encephalitozoonosis can modulate the host's immune system.
J Y Niederkorn, and
J A Shadduck, and
E C Schmidt
June 1995,
Antimicrobial agents and chemotherapy,
J Y Niederkorn, and
J A Shadduck, and
E C Schmidt
November 1995,
Parasitology,
J Y Niederkorn, and
J A Shadduck, and
E C Schmidt
March 1999,
Veterinary parasitology,
J Y Niederkorn, and
J A Shadduck, and
E C Schmidt
January 1997,
Parasitology,
J Y Niederkorn, and
J A Shadduck, and
E C Schmidt
April 1981,
Infection and immunity,
J Y Niederkorn, and
J A Shadduck, and
E C Schmidt
April 1974,
Journal of immunology (Baltimore, Md. : 1950),
J Y Niederkorn, and
J A Shadduck, and
E C Schmidt
January 1968,
Meditsinskaia parazitologiia i parazitarnye bolezni,
J Y Niederkorn, and
J A Shadduck, and
E C Schmidt
October 2002,
Revista de saude publica,
J Y Niederkorn, and
J A Shadduck, and
E C Schmidt
October 1985,
Atherosclerosis,
J Y Niederkorn, and
J A Shadduck, and
E C Schmidt
January 2003,
Tuberculosis (Edinburgh, Scotland),
