BIOMAT Database Logo BIOMAT Database Logo

Study of enamine derivatives of phenylglycine as adjuvants for the rectal absorption of insulin. 1981

A Kamada, and T Nishihata, and S Kim, and M Yamamoto, and N Yata

UI MeSH Term Description Entries
D007328 Insulin A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1). Iletin,Insulin A Chain,Insulin B Chain,Insulin, Regular,Novolin,Sodium Insulin,Soluble Insulin,Chain, Insulin B,Insulin, Sodium,Insulin, Soluble,Regular Insulin
D007408 Intestinal Absorption Uptake of substances through the lining of the INTESTINES. Absorption, Intestinal
D008297 Male Males
D011817 Rabbits A burrowing plant-eating mammal with hind limbs that are longer than its fore limbs. It belongs to the family Leporidae of the order Lagomorpha, and in contrast to hares, possesses 22 instead of 24 pairs of chromosomes. Belgian Hare,New Zealand Rabbit,New Zealand Rabbits,New Zealand White Rabbit,Rabbit,Rabbit, Domestic,Chinchilla Rabbits,NZW Rabbits,New Zealand White Rabbits,Oryctolagus cuniculus,Chinchilla Rabbit,Domestic Rabbit,Domestic Rabbits,Hare, Belgian,NZW Rabbit,Rabbit, Chinchilla,Rabbit, NZW,Rabbit, New Zealand,Rabbits, Chinchilla,Rabbits, Domestic,Rabbits, NZW,Rabbits, New Zealand,Zealand Rabbit, New,Zealand Rabbits, New,cuniculus, Oryctolagus
D011919 Rats, Inbred Strains Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding. August Rats,Inbred Rat Strains,Inbred Strain of Rat,Inbred Strain of Rats,Inbred Strains of Rats,Rat, Inbred Strain,August Rat,Inbred Rat Strain,Inbred Strain Rat,Inbred Strain Rats,Inbred Strains Rat,Inbred Strains Rats,Rat Inbred Strain,Rat Inbred Strains,Rat Strain, Inbred,Rat Strains, Inbred,Rat, August,Rat, Inbred Strains,Rats Inbred Strain,Rats Inbred Strains,Rats, August,Rats, Inbred Strain,Strain Rat, Inbred,Strain Rats, Inbred,Strain, Inbred Rat,Strains, Inbred Rat
D004285 Dogs The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065) Canis familiaris,Dog
D005998 Glycine A non-essential amino acid. It is found primarily in gelatin and silk fibroin and used therapeutically as a nutrient. It is also a fast inhibitory neurotransmitter. Aminoacetic Acid,Glycine, Monopotassium Salt,Glycine Carbonate (1:1), Monosodium Salt,Glycine Carbonate (2:1), Monolithium Salt,Glycine Carbonate (2:1), Monopotassium Salt,Glycine Carbonate (2:1), Monosodium Salt,Glycine Hydrochloride,Glycine Hydrochloride (2:1),Glycine Phosphate,Glycine Phosphate (1:1),Glycine Sulfate (3:1),Glycine, Calcium Salt,Glycine, Calcium Salt (2:1),Glycine, Cobalt Salt,Glycine, Copper Salt,Glycine, Monoammonium Salt,Glycine, Monosodium Salt,Glycine, Sodium Hydrogen Carbonate,Acid, Aminoacetic,Calcium Salt Glycine,Cobalt Salt Glycine,Copper Salt Glycine,Hydrochloride, Glycine,Monoammonium Salt Glycine,Monopotassium Salt Glycine,Monosodium Salt Glycine,Phosphate, Glycine,Salt Glycine, Monoammonium,Salt Glycine, Monopotassium,Salt Glycine, Monosodium
D000277 Adjuvants, Pharmaceutic Agents that aid or increase the action of the principle drug (DRUG SYNERGISM) or that affect the absorption, mechanism of action, metabolism, or excretion of the primary drug (PHARMACOKINETICS) in such a way as to enhance its effects. Adjuvant, Pharmaceutic,Adjuvant, Pharmaceutical,Adjuvants, Pharmaceutical,Pharmaceutic Adjuvant,Pharmaceutic Adjuvants,Pharmaceutical Adjuvant,Pharmaceutical Adjuvants
D000588 Amines A group of compounds derived from ammonia by substituting organic radicals for the hydrogens. (From Grant & Hackh's Chemical Dictionary, 5th ed) Amine
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia

Related Publications

A Kamada, and T Nishihata, and S Kim, and M Yamamoto, and N Yata
Studies of absorption promoters for rectal delivery preparations. II. A possible mechanism of promoting efficacy of enamine derivatives in rectal absorption.
February 1982, Chemical & pharmaceutical bulletin,
A Kamada, and T Nishihata, and S Kim, and M Yamamoto, and N Yata
Studies on absorption promoters for rectal delivery preparations. I. Promoting efficacy of enamine derivatives of amino acids for the rectal absorption of beta-lactam antibiotics in rabbits.
July 1981, Chemical & pharmaceutical bulletin,
A Kamada, and T Nishihata, and S Kim, and M Yamamoto, and N Yata
Enhancement of rectal absorption of drugs by adjuvants.
June 1980, Journal of pharmaceutical sciences,
A Kamada, and T Nishihata, and S Kim, and M Yamamoto, and N Yata
Phenylglycine derivatives as antagonists of metabotropic glutamate receptors.
September 1994, Trends in pharmacological sciences,
A Kamada, and T Nishihata, and S Kim, and M Yamamoto, and N Yata
The influence of concentration of two salicylate derivatives on rectal insulin absorption enhancement.
September 1988, The Journal of pharmacy and pharmacology,
A Kamada, and T Nishihata, and S Kim, and M Yamamoto, and N Yata
Use of adjuvants for enhancement of rectal absorption of cefoxitin in humans.
August 1985, Antimicrobial agents and chemotherapy,
A Kamada, and T Nishihata, and S Kim, and M Yamamoto, and N Yata
Evidence of D-phenylglycine as delivering tool for improving L-dopa absorption.
September 2010, Journal of biomedical science,
A Kamada, and T Nishihata, and S Kim, and M Yamamoto, and N Yata
Absorption-promoting adjuvants: animal studies on their effects on rectal drug absorption.
September 1984, Methods and findings in experimental and clinical pharmacology,
A Kamada, and T Nishihata, and S Kim, and M Yamamoto, and N Yata
Genotoxic activity of halogenated phenylglycine derivatives.
December 2006, Bioorganic & medicinal chemistry letters,
A Kamada, and T Nishihata, and S Kim, and M Yamamoto, and N Yata
Ethoxylated rapeseed oil derivatives as novel adjuvants for herbicides.
December 2002, Pest management science,
Copied contents to your clipboard!