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[Preparation of highly potent lyophilized tetanus antitoxin (author's transl)]. 1981

R J Huang, and M Y Liau, and J D Lee

The neutralizing antibody titre of tetanus antitoxin could be elevated 3.19 times by the purification of the antitoxin with pepsin digestion method, which is superior to ammonium sulfate salting out method by 1.5 times. But the antitoxin recovery rate by the pepsin digestion method was about 65.37% of the salting out method. Addition of 2% glycine significantly improved the solubility of lyophilized antitoxin. The effective period of liquid antitoxin was 1 year, while that of lyophilized products could be as long as 5 years.

UI MeSH Term Description Entries
D010434 Pepsin A Formed from pig pepsinogen by cleavage of one peptide bond. The enzyme is a single polypeptide chain and is inhibited by methyl 2-diaazoacetamidohexanoate. It cleaves peptides preferentially at the carbonyl linkages of phenylalanine or leucine and acts as the principal digestive enzyme of gastric juice. Pepsin,Pepsin 1,Pepsin 3
D005612 Freeze Drying Method of tissue preparation in which the tissue specimen is frozen and then dehydrated at low temperature in a high vacuum. This method is also used for dehydrating pharmaceutical and food products. Lyophilization,Drying, Freeze,Dryings, Freeze,Freeze Dryings,Lyophilizations
D013743 Tetanus Antitoxin An antitoxin used for the treatment of TETANUS. Antitoxin, Tetanus

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