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The effect of Lactobacillus casei YIT 9018 (LC 9018) on the growth of transplantable allogeneic and syngeneic mouse tumors was studied. Intraperitoneal treatment of LC 9018 caused a significant prolongation of the life span of ICR mice inoculated with sarcoma-180 intraperitoneally and BDF1 mice inoculated with L1210 leukemia intraperitoneally. Intravenous injection of LC 9018 markedly inhibited the growth of subcutaneously inoculated sarcoma-180. This organism was also effective against methylcholanthrene-induced syngeneic MCA K-1 tumor in BALB/c mice. The antitumor activity of LC 9018 was reduced by treatment with carrageenan, an anti-macrophage agent, and was also observed in T-cell deficient athymic nude mice. These results suggested that the antitumor activity of LC 9018 may be macrophage-dependent.
I Kato, and
S Kobayashi, and
T Yokokura, and
M Mutai
January 1984,
Gan,
I Kato, and
S Kobayashi, and
T Yokokura, and
M Mutai
September 1987,
Journal of leukocyte biology,
I Kato, and
S Kobayashi, and
T Yokokura, and
M Mutai
January 1988,
Cancer immunology, immunotherapy : CII,
I Kato, and
S Kobayashi, and
T Yokokura, and
M Mutai
January 1984,
Medical microbiology and immunology,
I Kato, and
S Kobayashi, and
T Yokokura, and
M Mutai
September 1987,
Nihon Hinyokika Gakkai zasshi. The japanese journal of urology,
I Kato, and
S Kobayashi, and
T Yokokura, and
M Mutai
July 1990,
Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases,
I Kato, and
S Kobayashi, and
T Yokokura, and
M Mutai
March 1984,
Gan to kagaku ryoho. Cancer & chemotherapy,
I Kato, and
S Kobayashi, and
T Yokokura, and
M Mutai
November 1984,
Gan to kagaku ryoho. Cancer & chemotherapy,
I Kato, and
S Kobayashi, and
T Yokokura, and
M Mutai
September 1967,
British medical journal,
I Kato, and
S Kobayashi, and
T Yokokura, and
M Mutai
January 1988,
Cancer immunology, immunotherapy : CII,
