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A study was conducted to find whether a deficiency in prostacyclin (prostaglandin I2; PGI2) is implicated in the pathogenesis of thrombotic thrombocytopenic purpura. Plasma samples from two patients with the disease before treatment and from 22 healthy controls were therefore assayed for concentrations of 6-oxo-PGF1 alpha and thromboxane B2, the stable metabolites of PGI2 and thromboxane A2, respectively. Neither of the patients responded to treatment, which in one case included an infusion of PGI2. Both patients had normal concentrations of 6-oxo-PGF1 alpha and thromboxane B2, thus implying that circulating amounts of PGI2 and thromboxane A2 were also normal. These findings suggest that 6-oxo-PGF1 alpha may be detectable in normal amounts in thrombotic thrombocytopenic purpura and that the condition need not be associated with a high concentration of thromboxane A2.
S H Lee, and
J S Wainscoat, and
H Zeitlin, and
F G Bolton, and
H A Leaver, and
A Seawright, and
J M Preece
October 1979,
Lancet (London, England),
S H Lee, and
J S Wainscoat, and
H Zeitlin, and
F G Bolton, and
H A Leaver, and
A Seawright, and
J M Preece
September 1981,
Annals of internal medicine,
S H Lee, and
J S Wainscoat, and
H Zeitlin, and
F G Bolton, and
H A Leaver, and
A Seawright, and
J M Preece
October 1980,
Lancet (London, England),
S H Lee, and
J S Wainscoat, and
H Zeitlin, and
F G Bolton, and
H A Leaver, and
A Seawright, and
J M Preece
July 1989,
British journal of haematology,
S H Lee, and
J S Wainscoat, and
H Zeitlin, and
F G Bolton, and
H A Leaver, and
A Seawright, and
J M Preece
June 1983,
Thrombosis research,
S H Lee, and
J S Wainscoat, and
H Zeitlin, and
F G Bolton, and
H A Leaver, and
A Seawright, and
J M Preece
March 1982,
Lancet (London, England),
S H Lee, and
J S Wainscoat, and
H Zeitlin, and
F G Bolton, and
H A Leaver, and
A Seawright, and
J M Preece
August 1981,
Thrombosis and haemostasis,
S H Lee, and
J S Wainscoat, and
H Zeitlin, and
F G Bolton, and
H A Leaver, and
A Seawright, and
J M Preece
February 1982,
Lancet (London, England),
S H Lee, and
J S Wainscoat, and
H Zeitlin, and
F G Bolton, and
H A Leaver, and
A Seawright, and
J M Preece
August 1981,
Lancet (London, England),
S H Lee, and
J S Wainscoat, and
H Zeitlin, and
F G Bolton, and
H A Leaver, and
A Seawright, and
J M Preece
January 1985,
The Journal of clinical investigation,
