Biomaterial Database

Genetic control of the immune response to myoglobin. VII. Antibody responses to myoglobin variants reveal that gene restriction of the antibody responses to myoglobin antigenic sites is dependent on the chemical properties of the sites. 1981

C R Young, and G P O'Connor, and M Z Atassi

Previously it has been shown that the immune responses to sperm-whale myoglobin are under H-2-linked Ir-gene control. More importantly the responses to the synthetic antigenic sites are each under separate genetic control. In the present studies we investigated the genetic control of the antibody response to four different myoglobins of known structure, to determine whether this genetic control is influenced by changes in the properties of the sites. The results suggest that genetic control of the responses to individual antigenic sites on a protein antigen is not only determined by the genetic constitution of the host species but also by the chemical properties of the individual sites. It appears that the H-2 subregions mapping the responses to given antigenic sites can also recognize other sites, which were previously unrecognizable in a homologous protein, if their chemical properties are suitably altered.

UI	MeSH Term	Description	Entries
D008805	Mice, Inbred A	An inbred strain of mouse that is widely used in IMMUNOLOGY studies and cancer research.	Mouse, Inbred A,Inbred A Mice,Inbred A Mouse
D008806	Mice, Inbred AKR	An inbred strain of mouse that is widely used in IMMUNOLOGY studies and cancer research.	Mice, AKR,Mouse, AKR,Mouse, Inbred AKR,AKR Mice,AKR Mice, Inbred,AKR Mouse,AKR Mouse, Inbred,Inbred AKR Mice,Inbred AKR Mouse
D008807	Mice, Inbred BALB C	An inbred strain of mouse that is widely used in IMMUNOLOGY studies and cancer research.	BALB C Mice, Inbred,BALB C Mouse, Inbred,Inbred BALB C Mice,Inbred BALB C Mouse,Mice, BALB C,Mouse, BALB C,Mouse, Inbred BALB C,BALB C Mice,BALB C Mouse
D008808	Mice, Inbred CBA	An inbred strain of mouse that is widely used in BIOMEDICAL RESEARCH.	Mice, CBA,Mouse, CBA,Mouse, Inbred CBA,CBA Mice,CBA Mice, Inbred,CBA Mouse,CBA Mouse, Inbred,Inbred CBA Mice,Inbred CBA Mouse
D008809	Mice, Inbred C3H	An inbred strain of mouse that is used as a general purpose strain in a wide variety of RESEARCH areas including CANCER; INFECTIOUS DISEASES; sensorineural, and cardiovascular biology research.	Mice, C3H,Mouse, C3H,Mouse, Inbred C3H,C3H Mice,C3H Mice, Inbred,C3H Mouse,C3H Mouse, Inbred,Inbred C3H Mice,Inbred C3H Mouse
D008810	Mice, Inbred C57BL	One of the first INBRED MOUSE STRAINS to be sequenced. This strain is commonly used as genetic background for transgenic mouse models. Refractory to many tumors, this strain is also preferred model for studying role of genetic variations in development of diseases.	Mice, C57BL,Mouse, C57BL,Mouse, Inbred C57BL,C57BL Mice,C57BL Mice, Inbred,C57BL Mouse,C57BL Mouse, Inbred,Inbred C57BL Mice,Inbred C57BL Mouse
D008811	Mice, Inbred DBA	An inbred strain of mouse. Specific substrains are used in a variety of areas of BIOMEDICAL RESEARCH such as DBA/1J, which is used as a model for RHEUMATOID ARTHRITIS.	Mice, DBA,Mouse, DBA,Mouse, Inbred DBA,DBA Mice,DBA Mice, Inbred,DBA Mouse,DBA Mouse, Inbred,Inbred DBA Mice,Inbred DBA Mouse
D009211	Myoglobin	A conjugated protein which is the oxygen-transporting pigment of muscle. It is made up of one globin polypeptide chain and one heme group.
D011487	Protein Conformation	The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).	Conformation, Protein,Conformations, Protein,Protein Conformations
D004289	Dolphins	Mammals of the families Delphinidae (ocean dolphins), Iniidae, Lipotidae, Pontoporiidae, and Platanistidae (all river dolphins). Among the most well-known species are the BOTTLE-NOSED DOLPHIN and the KILLER WHALE (a dolphin). The common name dolphin is applied to small cetaceans having a beaklike snout and a slender, streamlined body, whereas PORPOISES are small cetaceans with a blunt snout and rather stocky body. (From Walker's Mammals of the World, 5th ed, pp978-9)	Amazon Dolphins,Baiji,Cephalorhynchus,Chinese River Dolphin,Delphinidae,False Killer Whale,Franciscana,Fraser's Dolphin,Ganges Dolphin,Gray Grampus,Humpback Dolphins,Irrawaddy River Dolphin,La Plata Dolphin,Lagenorhynchus,Lissodelphis,Many-Toothed Blackfish,Marine Dolphins,Melon-Headed Whale,Ocean Dolphins,Piebald Dolphins,Platanista,Pontoporia blainvillei,Pygmy Killer Whale,Right Whale Dolphins,Risso's Dolphin,Rough-Toothed Dolphin,Sousa,Susus,Tucuxi Dolphin,Whale, False Killer,Whale, Melon-Headed,Whale, Pygmy Killer,White-Beaked Dolphins,Amazon River Dolphins,Atlantic White-Sided Dolphins,Feresa attenuata,Ganges River Dolphin,Grampus griseus,Inia geoffrensis,Lagenodelphis hosei,Lagenorhynchus acutus,Lagenorhynchus albirostris,Langenorhynchus obliquidens,Lipotes vexillifer,Orcaella brevirostris,Pacific White-Sided Dolphins,Peponocephala electra,Planista gangetica,Pseudorca crassidens,Sotalia fluviatilis,Steno bredanensis,Yangtze River Dolphin,Atlantic White Sided Dolphins,Atlantic White-Sided Dolphin,Baijus,Dolphin,Dolphin, Fraser's,False Killer Whales,Franciscanas,Fraser Dolphin,Frasers Dolphin,Humpback Dolphin,Lagenodelphis hoseus,Lagenorhynchus albirostri,Langenorhynchus obliquiden,Lissodelphi,Many Toothed Blackfish,Marine Dolphin,Melon Headed Whale,Melon-Headed Whales,Ocean Dolphin,Orcaella brevirostri,Pacific White Sided Dolphins,Pacific White-Sided Dolphin,Piebald Dolphin,Planista gangeticas,Platanistas,Pontoporia blainvilleus,Pseudorca crassiden,Pygmy Killer Whales,Right Whale Dolphin,Risso Dolphin,Rissos Dolphin,Rough Toothed Dolphin,Rough-Toothed Dolphins,Sotalia fluviatili,Tucuxi Dolphins,White Beaked Dolphins,White-Beaked Dolphin