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The combined effect of beta-lactam antibiotics and 9,3"-di-O-acetylmidecamycin were examined in 10 patients diagnosed as having chronic respiratory tract infections and complicated urinary tract infections. Patients were initially treated with 3 to 10 g/day of beta-lactams as intravenous infusions or by oral route for a certain period, after which period they were treated concurrently with 0.3 to 0.9 g/day of 9,3"-di-O-acetylmidecamycin by oral route. Through this combination therapy eradication of P. aeruginosa was obtained in 2 cases and remarkable decrease in another 2 cases out of the 10 cases. This combination therapy was judged to be effective in these 4 cases. Of the remaining cases, P. aeruginosa was eliminated before the start of the combination therapy in 3 cases, and no change in bacterial count was noted after the combination therapy in the other 3 cases.
K Mashimo, and
J Y Homma, and
Y Iki, and
K Inatomi, and
T Kasai, and
O Kunii, and
K Shimada, and
H Tanimoto, and
T Takigami, and
Y Nishimura
June 1986,
The Japanese journal of antibiotics,
K Mashimo, and
J Y Homma, and
Y Iki, and
K Inatomi, and
T Kasai, and
O Kunii, and
K Shimada, and
H Tanimoto, and
T Takigami, and
Y Nishimura
February 1986,
Arzneimittel-Forschung,
K Mashimo, and
J Y Homma, and
Y Iki, and
K Inatomi, and
T Kasai, and
O Kunii, and
K Shimada, and
H Tanimoto, and
T Takigami, and
Y Nishimura
February 1985,
Chemioterapia : international journal of the Mediterranean Society of Chemotherapy,
K Mashimo, and
J Y Homma, and
Y Iki, and
K Inatomi, and
T Kasai, and
O Kunii, and
K Shimada, and
H Tanimoto, and
T Takigami, and
Y Nishimura
April 1981,
The Journal of antibiotics,
K Mashimo, and
J Y Homma, and
Y Iki, and
K Inatomi, and
T Kasai, and
O Kunii, and
K Shimada, and
H Tanimoto, and
T Takigami, and
Y Nishimura
November 1982,
Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases,
K Mashimo, and
J Y Homma, and
Y Iki, and
K Inatomi, and
T Kasai, and
O Kunii, and
K Shimada, and
H Tanimoto, and
T Takigami, and
Y Nishimura
January 1985,
Chemotherapy,
K Mashimo, and
J Y Homma, and
Y Iki, and
K Inatomi, and
T Kasai, and
O Kunii, and
K Shimada, and
H Tanimoto, and
T Takigami, and
Y Nishimura
September 1983,
The Journal of antimicrobial chemotherapy,
K Mashimo, and
J Y Homma, and
Y Iki, and
K Inatomi, and
T Kasai, and
O Kunii, and
K Shimada, and
H Tanimoto, and
T Takigami, and
Y Nishimura
April 1984,
The Journal of antimicrobial chemotherapy,
K Mashimo, and
J Y Homma, and
Y Iki, and
K Inatomi, and
T Kasai, and
O Kunii, and
K Shimada, and
H Tanimoto, and
T Takigami, and
Y Nishimura
June 1982,
Shigaku = Odontology; journal of Nihon Dental College,
K Mashimo, and
J Y Homma, and
Y Iki, and
K Inatomi, and
T Kasai, and
O Kunii, and
K Shimada, and
H Tanimoto, and
T Takigami, and
Y Nishimura
January 1987,
Folia microbiologica,
