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Nine of 15 specimens of human origin thought to contain non-A, non-B hepatitis agents caused hepatitis in recipient chimpanzees. Two have been further characterized. One inoculum, designated strain F, has been reported to produce unique cytoplasmic changes detected by electron microscopy in liver biopsy specimens; the other, strain H, produced distinctive nuclear changes. It is not yet clear whether these two changes result from infection by different agents; they have been useful markers of non-A, non-B hepatitis in chimpanzees. Strain F was serially passaged six times in chimpanzees, and the infectivity titer of the strain F plasma was estimated to be less than 10(2)/ml. Strain H had an infectivity titer in chimpanzees of at least 10(6)/ml. Both the strain F and strain H agents have been successfully transmitted and serially passaged in marmosets. Although hepatitis was detected in a lower percentage of marmosets than chimpanzees given either the strain F or H inoculum, the infectivity titer of the strain H agent appeared to be greater than or equal to 10(8) marmoset infectious doses/ml.
S M Feinstone, and
H J Alter, and
H P Dienes, and
Y Shimizu, and
H Popper, and
D Blackmore, and
D Sly, and
W T London, and
R H Purcell
January 1983,
Journal of medical virology,
S M Feinstone, and
H J Alter, and
H P Dienes, and
Y Shimizu, and
H Popper, and
D Blackmore, and
D Sly, and
W T London, and
R H Purcell
February 1981,
The Journal of infectious diseases,
S M Feinstone, and
H J Alter, and
H P Dienes, and
Y Shimizu, and
H Popper, and
D Blackmore, and
D Sly, and
W T London, and
R H Purcell
January 1983,
Journal of medical virology,
S M Feinstone, and
H J Alter, and
H P Dienes, and
Y Shimizu, and
H Popper, and
D Blackmore, and
D Sly, and
W T London, and
R H Purcell
December 1982,
Proceedings of the National Academy of Sciences of the United States of America,
S M Feinstone, and
H J Alter, and
H P Dienes, and
Y Shimizu, and
H Popper, and
D Blackmore, and
D Sly, and
W T London, and
R H Purcell
June 1987,
Journal of medical virology,
S M Feinstone, and
H J Alter, and
H P Dienes, and
Y Shimizu, and
H Popper, and
D Blackmore, and
D Sly, and
W T London, and
R H Purcell
November 1979,
The Journal of infectious diseases,
S M Feinstone, and
H J Alter, and
H P Dienes, and
Y Shimizu, and
H Popper, and
D Blackmore, and
D Sly, and
W T London, and
R H Purcell
January 2000,
Current topics in microbiology and immunology,
S M Feinstone, and
H J Alter, and
H P Dienes, and
Y Shimizu, and
H Popper, and
D Blackmore, and
D Sly, and
W T London, and
R H Purcell
April 1985,
Journal of medical virology,
S M Feinstone, and
H J Alter, and
H P Dienes, and
Y Shimizu, and
H Popper, and
D Blackmore, and
D Sly, and
W T London, and
R H Purcell
June 1986,
Liver,
S M Feinstone, and
H J Alter, and
H P Dienes, and
Y Shimizu, and
H Popper, and
D Blackmore, and
D Sly, and
W T London, and
R H Purcell
April 1983,
Liver,
