-transparent.png){kind=logo}
The neuromuscular blocking activity of netilmicin sulphate (Sch 20569), a new aminoglycoside antibiotic, was studied on the rat sciatic nerve-gastrocnemius muscle preparation. The i.v. administration of netilmicin caused a gradual fall, up to complete blockade, of the muscular contraction elicited by nerve stimulation. Conversely, the muscular response to direct stimulation was not affected. The response pattern was similar to that seen with known aminoglycoside antibiotics. The acute toxic effects (LD50 i.p. in mice) of netilmicin were antagonized by pretreatment with neostigmine; this latter partially prevented netilmicin-induced blockade, but was not able to reverse it. Calcium chloride was the only agent effective both to prevent and to reverse the neuromuscular blocking effects of netilmicin.
L Albiero, and
E Ongini, and
L Parravicini
July 1980,
Experientia,
L Albiero, and
E Ongini, and
L Parravicini
August 1982,
Drug and therapeutics bulletin,
L Albiero, and
E Ongini, and
L Parravicini
January 1978,
Chemotherapy,
L Albiero, and
E Ongini, and
L Parravicini
May 1979,
Revista clinica espanola,
L Albiero, and
E Ongini, and
L Parravicini
January 1982,
Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi,
L Albiero, and
E Ongini, and
L Parravicini
February 1980,
Methods and findings in experimental and clinical pharmacology,
L Albiero, and
E Ongini, and
L Parravicini
March 1977,
Antimicrobial agents and chemotherapy,
L Albiero, and
E Ongini, and
L Parravicini
June 1977,
Antimicrobial agents and chemotherapy,
L Albiero, and
E Ongini, and
L Parravicini
November 1976,
Antimicrobial agents and chemotherapy,
L Albiero, and
E Ongini, and
L Parravicini
September 1976,
Antimicrobial agents and chemotherapy,
