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Sodium-potassium cotransport activity is thought to be defective in essential hypertension and could be a useful genetic marker for susceptibility to essential hypertension. In this study cotransport activity in subjects with hypertension was compared with that in normotensive controls. The effects of ethnic differences, environment, and antihypertensive drugs were also studied. Mean cotransport activity was lower in hypertensive subjects than in controls of the same ethnic groups. There was, however, a large overlap between controls and hypertensive subjects. No ethnic or environmental influences were found. The large overlap found suggests that sodium-potassium cotransport activity is not a useful genetic marker in essential hypertension.
J S Davidson, and
L H Opie, and
B Keding
December 1980,
Clinical science (London, England : 1979),
J S Davidson, and
L H Opie, and
B Keding
January 1982,
Hypertension (Dallas, Tex. : 1979),
J S Davidson, and
L H Opie, and
B Keding
December 1993,
Journal of hypertension. Supplement : official journal of the International Society of Hypertension,
J S Davidson, and
L H Opie, and
B Keding
March 1986,
Japanese heart journal,
J S Davidson, and
L H Opie, and
B Keding
December 1981,
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J S Davidson, and
L H Opie, and
B Keding
January 1981,
Clinical and experimental hypertension,
J S Davidson, and
L H Opie, and
B Keding
January 2000,
Physiological reviews,
J S Davidson, and
L H Opie, and
B Keding
August 1981,
British medical journal (Clinical research ed.),
J S Davidson, and
L H Opie, and
B Keding
August 1990,
Journal of human hypertension,
J S Davidson, and
L H Opie, and
B Keding
January 1984,
Hypertension (Dallas, Tex. : 1979),
