-transparent.png){kind=logo}
The effect of apomorphine and haloperidol on DOPA accumulation after inhibition of DOPA decarboxylase activity with NSD 1015 was compared in the substantia nigra (SN) and caudate nucleus (CN) of normal rats and rats deprived of nigral afferences from the striatum by means of intrastriatal kainic acid. In normal rats apomorphine decreased DOPA accumulation to the same extent in both the SN and CN. However, haloperidol produced a more pronounced increase in DOPA accumulation in the CN than in the SN. The effect of both drugs still persisted in the SN and CN after destruction of the neuronal strionigral feedback loop with kainic acid. The results provide evidence for the existence of nigral dopamine autoreceptors controlling dopamine synthesis in the SN.
A Argiolas, and
M R Melis, and
F Fadda, and
G L Gessa
January 1985,
Neuropharmacology,
A Argiolas, and
M R Melis, and
F Fadda, and
G L Gessa
September 1976,
FEBS letters,
A Argiolas, and
M R Melis, and
F Fadda, and
G L Gessa
January 1991,
Neurobiology of aging,
A Argiolas, and
M R Melis, and
F Fadda, and
G L Gessa
March 2011,
Journal of neurochemistry,
A Argiolas, and
M R Melis, and
F Fadda, and
G L Gessa
March 1976,
Nature,
A Argiolas, and
M R Melis, and
F Fadda, and
G L Gessa
July 2003,
The Journal of neuroscience : the official journal of the Society for Neuroscience,
A Argiolas, and
M R Melis, and
F Fadda, and
G L Gessa
November 1980,
Brain research,
A Argiolas, and
M R Melis, and
F Fadda, and
G L Gessa
February 1984,
Brain research,
A Argiolas, and
M R Melis, and
F Fadda, and
G L Gessa
January 1988,
Acta histochemica. Supplementband,
A Argiolas, and
M R Melis, and
F Fadda, and
G L Gessa
January 1979,
Applied neurophysiology,
