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Rats, guinea pigs and monkeys were exposed by inhalation (6 hr/day, 5 days/week) for up to 22 months to a 13 mg/m3 concentration of PVC dust. Autopsies on rats and guinea pigs were performed after 12 months of exposure and on monkeys after 22 months after 22 months of exposure. Lung function tests were performed on monkeys after 9, 14 and 22 months of exposure. Aggregates of alveolar macrophages containing PVC particles were found in the lungs of all animals. These aggregates were more numerous in the monkey lungs. No fibrosis or significant cellular infiltrates were present in or near these cellular aggregates. No significant effects on pulmonary function could be demonstrated in the monkeys exposed to PVC. Under the conditions of this experiment, inhaled PVC produced a benign pneumoconiosis.
D H Groth, and
D W Lynch, and
W J Moorman, and
L E Stettler, and
T R Lewis, and
W D Wagner, and
C Kommineni
June 2003,
Occupational and environmental medicine,
D H Groth, and
D W Lynch, and
W J Moorman, and
L E Stettler, and
T R Lewis, and
W D Wagner, and
C Kommineni
October 1981,
Environmental health perspectives,
D H Groth, and
D W Lynch, and
W J Moorman, and
L E Stettler, and
T R Lewis, and
W D Wagner, and
C Kommineni
October 1981,
Environmental health perspectives,
D H Groth, and
D W Lynch, and
W J Moorman, and
L E Stettler, and
T R Lewis, and
W D Wagner, and
C Kommineni
October 1981,
Environmental health perspectives,
D H Groth, and
D W Lynch, and
W J Moorman, and
L E Stettler, and
T R Lewis, and
W D Wagner, and
C Kommineni
October 1983,
Environmental health perspectives,
D H Groth, and
D W Lynch, and
W J Moorman, and
L E Stettler, and
T R Lewis, and
W D Wagner, and
C Kommineni
March 1983,
Ceskoslovenska neurologie a neurochirurgie,
D H Groth, and
D W Lynch, and
W J Moorman, and
L E Stettler, and
T R Lewis, and
W D Wagner, and
C Kommineni
November 2017,
Wei sheng yan jiu = Journal of hygiene research,
D H Groth, and
D W Lynch, and
W J Moorman, and
L E Stettler, and
T R Lewis, and
W D Wagner, and
C Kommineni
January 1976,
Annals of the New York Academy of Sciences,
D H Groth, and
D W Lynch, and
W J Moorman, and
L E Stettler, and
T R Lewis, and
W D Wagner, and
C Kommineni
January 1970,
Giornale italiano delle malattie del torace,
D H Groth, and
D W Lynch, and
W J Moorman, and
L E Stettler, and
T R Lewis, and
W D Wagner, and
C Kommineni
January 2006,
International archives of occupational and environmental health,
