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Subjects in the National Cooperative Gallstone Study undergoing 12 mo of therapy with chenodeoxycholic acid for the dissolution of gallstones (low-dose, 375 mg/day, n =252; high-dose, 750 mg/day, n = 253) had a mean increase in serum cholesterol of 20 mg/dl as compared with a 5 mg/dl increase in the placebo group (n = 258). The effect of chenodeoxycholic acid on lipoproteins was determined in a random subset of the high-dose (n = 136) and placebo (n = 143) groups. For men, the mean baseline adjusted estimated low-density lipoprotein cholesterol level at 12 mo was significantly higher in the high-dose group than in the placebo group (159 vs. 148 mg/dl, p less than 0.01), whereas among women this difference was not demonstrated. Change in low-density lipoprotein cholesterol level was inversely related to baseline cholesterol to an equivalent degree in each group among men and women. Women in the high-dose group had significantly lower very-low-density lipoprotein cholesterol levels than did the corresponding placebo group (27 vs. 32 mg/dl, p less than 0.003). Very-low-density lipoprotein cholesterol levels did not differ significantly between the high-dose and placebo group in men. Treatment did not significantly affect the levels of high-density lipoprotein cholesterol or apoproteins A-I, A-II, or B. Chenodeoxycholic acid therapy produces an increase in total cholesterol and low-density lipoprotein cholesterol but does not alter high-density lipoprotein cholesterol levels.
J J Albers, and
S M Grundy, and
P A Cleary, and
D M Small, and
J M Lachin, and
L J Schoenfield
January 1982,
Journal of toxicology and environmental health,
J J Albers, and
S M Grundy, and
P A Cleary, and
D M Small, and
J M Lachin, and
L J Schoenfield
September 1981,
Annals of internal medicine,
J J Albers, and
S M Grundy, and
P A Cleary, and
D M Small, and
J M Lachin, and
L J Schoenfield
January 1982,
Hepatology (Baltimore, Md.),
J J Albers, and
S M Grundy, and
P A Cleary, and
D M Small, and
J M Lachin, and
L J Schoenfield
January 1983,
Hepatology (Baltimore, Md.),
J J Albers, and
S M Grundy, and
P A Cleary, and
D M Small, and
J M Lachin, and
L J Schoenfield
March 1978,
JAMA,
J J Albers, and
S M Grundy, and
P A Cleary, and
D M Small, and
J M Lachin, and
L J Schoenfield
March 1983,
Gastroenterology,
J J Albers, and
S M Grundy, and
P A Cleary, and
D M Small, and
J M Lachin, and
L J Schoenfield
May 1979,
Clinical pharmacology and therapeutics,
J J Albers, and
S M Grundy, and
P A Cleary, and
D M Small, and
J M Lachin, and
L J Schoenfield
December 1977,
The American journal of digestive diseases,
J J Albers, and
S M Grundy, and
P A Cleary, and
D M Small, and
J M Lachin, and
L J Schoenfield
February 1973,
Lancet (London, England),
J J Albers, and
S M Grundy, and
P A Cleary, and
D M Small, and
J M Lachin, and
L J Schoenfield
January 1973,
Lancet (London, England),
