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Di-n-propylacetate (DPA), aminooxyacetic acid (AOAA), and gabaculine were administered alone or in combination to Swiss mice. Six hours after administration of the drugs the anticonvulsant action (against isonicotinic acid hydrazide-induced seizures) of AOAA and DPA combined was less than that of AOAA alone. The cause of this phenomenon appeared to be an interaction between DPA and AOAA with respect to inhibition of GABA-T activity, resulting in a long-term diminished inhibition by AOAA, which in turn led to a lessening of the AOAA-induced elevation in the GABA content of nerve endings (synaptosomes). An excellent correlation was observed between the delay in onset of seizures and the elevation of synaptosomal GABA content.
J D Wood, and
E Kurylo, and
S K Tsui
April 1979,
Biochemical pharmacology,
J D Wood, and
E Kurylo, and
S K Tsui
March 1976,
British journal of pharmacology,
J D Wood, and
E Kurylo, and
S K Tsui
January 1978,
General pharmacology,
J D Wood, and
E Kurylo, and
S K Tsui
January 1990,
Clinical and experimental pharmacology & physiology,
J D Wood, and
E Kurylo, and
S K Tsui
April 1981,
Biulleten' eksperimental'noi biologii i meditsiny,
J D Wood, and
E Kurylo, and
S K Tsui
February 1976,
Biochemical pharmacology,
J D Wood, and
E Kurylo, and
S K Tsui
February 1977,
European journal of pharmacology,
J D Wood, and
E Kurylo, and
S K Tsui
June 1967,
Biochemical pharmacology,
J D Wood, and
E Kurylo, and
S K Tsui
September 1972,
Comptes rendus hebdomadaires des seances de l'Academie des sciences. Serie D: Sciences naturelles,
J D Wood, and
E Kurylo, and
S K Tsui
February 1976,
Arzneimittel-Forschung,
