Biomaterial Database

Use of serum theophylline determinations during acute asthma therapy in children. 1982

G L Kearns, and T J Fischer, and R H Hunter

Analyses of 90 admissions to the Cincinnati Children's Hospital Center, Cincinnati, Ohio, were used to assess the effects of the routine availability of serum theophylline determinations (STD) in treating acute in-hospital asthma over three one-year review periods coinciding with the relative availability of STD. Significant differences were found between the first and third periods for the mean outpatient theophylline dose used on admission, the mean initial in-hospital intravenous dose, the mean initial oral dose during admission and the mean oral discharge dose. No statistical differences were noted in the length of hospital stay, duration of intravenous therapy or report of theophylline toxicity (despite the use of larger theophylline doses). Utilization of STD must be guided by cost-effective pharmacokinetic principles.

UI	MeSH Term	Description	Entries
D007223	Infant	A child between 1 and 23 months of age.	Infants
D007700	Kinetics	The rate dynamics in chemical or physical systems.
D008297	Male		Males
D002648	Child	A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL.	Children
D002673	Child, Hospitalized	Child hospitalized for short term care.	Hospitalized Child,Children, Hospitalized,Hospitalized Children
D002675	Child, Preschool	A child between the ages of 2 and 5.	Children, Preschool,Preschool Child,Preschool Children
D003362	Cost-Benefit Analysis	A method of comparing the cost of a program with its expected benefits in dollars (or other currency). The benefit-to-cost ratio is a measure of total return expected per unit of money spent. This analysis generally excludes consideration of factors that are not measured ultimately in economic terms. In contrast a cost effectiveness in general compares cost with qualitative outcomes.	Cost and Benefit,Cost-Benefit Data,Benefits and Costs,Cost Benefit,Cost Benefit Analysis,Cost-Utility Analysis,Costs and Benefits,Economic Evaluation,Marginal Analysis,Analyses, Cost Benefit,Analysis, Cost Benefit,Analysis, Cost-Benefit,Analysis, Cost-Utility,Analysis, Marginal,Benefit and Cost,Cost Benefit Analyses,Cost Benefit Data,Cost Utility Analysis,Cost-Benefit Analyses,Cost-Utility Analyses,Data, Cost-Benefit,Economic Evaluations,Evaluation, Economic,Marginal Analyses
D005260	Female		Females
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000208	Acute Disease	Disease having a short and relatively severe course.	Acute Diseases,Disease, Acute,Diseases, Acute