Biomaterial Database

[Ontogeny of cardiac antigens in chickens]. 1981

R D Martínez, and P Loza, and C Salinas, and L Muñoz

The embryonic development of the heart is a complex process in which molecular events take place during the cellular recognition, growth regulation and morphogenesis. In this work, the stage in which cardiac antigens are produced in the chick embryo was established by the use of sera directed against cockerel's heart antigens. Chick embryos were studied in different stages of development, classified according to the Hamburger and Hamilton system. Soluble and insoluble fraction of the cockerel's heart were obtained and used to immunize rabbits; the presence of anti-heart antibodies was tested by double microimmunodiffusion. Antisera to yolk and albumin envelopment, serum and cockerel erythocytes were also produced in order to recognize other molecules in the embryos. Anticockerel red cells antibodies were determined by direct hemaglutination. It was shown that heart antigens appear since the second stage of embryonic development and remain during the whole development, although in some stages it seems that the concentration of some antigens decreases. It is possible that the molecular changes in the heart tissue are manifested as variations in concentration of the cardiac substances.

UI	MeSH Term	Description	Entries
D007106	Immune Sera	Serum that contains antibodies. It is obtained from an animal that has been immunized either by ANTIGEN injection or infection with microorganisms containing the antigen.	Antisera,Immune Serums,Sera, Immune,Serums, Immune
D009206	Myocardium	The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.	Muscle, Cardiac,Muscle, Heart,Cardiac Muscle,Myocardia,Cardiac Muscles,Heart Muscle,Heart Muscles,Muscles, Cardiac,Muscles, Heart
D002642	Chick Embryo	The developmental entity of a fertilized chicken egg (ZYGOTE). The developmental process begins about 24 h before the egg is laid at the BLASTODISC, a small whitish spot on the surface of the EGG YOLK. After 21 days of incubation, the embryo is fully developed before hatching.	Embryo, Chick,Chick Embryos,Embryos, Chick
D004912	Erythrocytes	Red blood cells. Mature erythrocytes are non-nucleated, biconcave disks containing HEMOGLOBIN whose function is to transport OXYGEN.	Blood Cells, Red,Blood Corpuscles, Red,Red Blood Cells,Red Blood Corpuscles,Blood Cell, Red,Blood Corpuscle, Red,Erythrocyte,Red Blood Cell,Red Blood Corpuscle
D005779	Immunodiffusion	Technique involving the diffusion of antigen or antibody through a semisolid medium, usually agar or agarose gel, with the result being a precipitin reaction.	Gel Diffusion Tests,Diffusion Test, Gel,Diffusion Tests, Gel,Gel Diffusion Test,Immunodiffusions,Test, Gel Diffusion,Tests, Gel Diffusion
D006321	Heart	The hollow, muscular organ that maintains the circulation of the blood.	Hearts
D006386	Hemagglutination Tests	Sensitive tests to measure certain antigens, antibodies, or viruses, using their ability to agglutinate certain erythrocytes. (From Stedman, 26th ed)	Hemagglutination Test,Test, Hemagglutination,Tests, Hemagglutination
D000418	Albumins	Water-soluble proteins found in egg whites, blood, lymph, and other tissues and fluids. They coagulate upon heating.	Albumin
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D000941	Antigens	Substances that are recognized by the immune system and induce an immune reaction.	Antigen