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The forearms of six patients with Duchenne dystrophy were examined by the painless and non-invasive technique of high-resolution nuclear magnetic resonance spectroscopy. The phosphorus spectrum was abnormal in that the ratios of phosphocreatine to adenosine triphosphate and to inorganic phosphate were reduced. Absolute quantification under the conditions of this experiment was not possible but it was probable that in dystrophy the concentration of phosphocreatine in muscle was appreciably reduced. A signal in the phosphodiester region of the spectrum was recorded consistently in patients with dystrophy but not in controls. The intracellular pH of the muscle in the dystrophic patients was abnormally alkaline. The clinical application of nuclear magnetic resonance spectroscopy remains to be proved, but it appears to be a promising non-invasive technique for investigating biochemical abnormalities of muscle disease.
R J Newman, and
P J Bore, and
L Chan, and
D G Gadian, and
P Styles, and
D Taylor, and
G K Radda
May 1992,
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques,
R J Newman, and
P J Bore, and
L Chan, and
D G Gadian, and
P Styles, and
D Taylor, and
G K Radda
May 1981,
Biochemical and biophysical research communications,
R J Newman, and
P J Bore, and
L Chan, and
D G Gadian, and
P Styles, and
D Taylor, and
G K Radda
November 1988,
Rinsho shinkeigaku = Clinical neurology,
R J Newman, and
P J Bore, and
L Chan, and
D G Gadian, and
P Styles, and
D Taylor, and
G K Radda
February 1965,
Science (New York, N.Y.),
R J Newman, and
P J Bore, and
L Chan, and
D G Gadian, and
P Styles, and
D Taylor, and
G K Radda
January 1991,
No to hattatsu = Brain and development,
R J Newman, and
P J Bore, and
L Chan, and
D G Gadian, and
P Styles, and
D Taylor, and
G K Radda
January 2009,
Journal of computer assisted tomography,
R J Newman, and
P J Bore, and
L Chan, and
D G Gadian, and
P Styles, and
D Taylor, and
G K Radda
September 2017,
Annals of clinical and translational neurology,
R J Newman, and
P J Bore, and
L Chan, and
D G Gadian, and
P Styles, and
D Taylor, and
G K Radda
May 2023,
Journal of clinical ultrasound : JCU,
R J Newman, and
P J Bore, and
L Chan, and
D G Gadian, and
P Styles, and
D Taylor, and
G K Radda
May 2022,
Neuromuscular disorders : NMD,
R J Newman, and
P J Bore, and
L Chan, and
D G Gadian, and
P Styles, and
D Taylor, and
G K Radda
January 1978,
The Biochemical journal,
