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The transformer-2 (tra-2) locus is one of a set of regulatory loci that control sex determination in Drosophila melanogaster. Temperature-shift experiments with temperature-sensitive tra-2 mutants demonstrate that within single cell lineages tra-2+ function is required at several times, and probably continuously, during development for the occurrence of a series of determinative decisions necessary for female sexual differentiation. Analysis of the effects of tra-2 in the genital disc demonstrates that the tra-2+ function is necessary in females both to prevent male sexual differentiation and to permit female differentiation. These and other results support the model that the tra-2+ and tra+ loci act to control the expression of the bifunctional doublesex (dsx) locus.
J M Belote, and
B S Baker
March 1989,
Cell,
J M Belote, and
B S Baker
April 1994,
Genetics,
J M Belote, and
B S Baker
June 1990,
The Quarterly review of biology,
J M Belote, and
B S Baker
April 1992,
Genetics,
J M Belote, and
B S Baker
September 1993,
Development (Cambridge, England),
J M Belote, and
B S Baker
August 1990,
Trends in genetics : TIG,
J M Belote, and
B S Baker
January 1994,
Genetics,
J M Belote, and
B S Baker
October 1991,
Genetics,
J M Belote, and
B S Baker
June 1991,
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme,
