-transparent.png){kind=logo}
Infusion of PGI2 at a dose of 5 or 10 ng/kg/min during 72 hours into patients with peripheral vascular disease was followed by increased susceptibility of platelets to proaggregatory action of ADP and collagen but not that of arachidonate. The above effects were observed 24 hours after termination of infusion of PGI2. A tendency to an increased formation of TXA2 in PRP aggregated by arachidonate was also noticed. Infusion of PGI2 at a dose of 2 mg/kg/min during 72 hours into the patients caused the decreased platelet aggregability to ADP and arachidonate but not to collagen, and a decreased tendency to production of TXA2 in PRP aggregated by arachidonate. The existence of a "rebound effect" in platelets after a long term PGI2 therapy is suggested.
A Dembinska-Kiec, and
A Zmuda, and
L Grodzinska, and
K Bieron, and
M Basista, and
A Kedzior, and
E Kostka-Trabka, and
E Telesz, and
T Zelazny
August 1978,
Thrombosis research,
A Dembinska-Kiec, and
A Zmuda, and
L Grodzinska, and
K Bieron, and
M Basista, and
A Kedzior, and
E Kostka-Trabka, and
E Telesz, and
T Zelazny
January 1980,
Thrombosis research,
A Dembinska-Kiec, and
A Zmuda, and
L Grodzinska, and
K Bieron, and
M Basista, and
A Kedzior, and
E Kostka-Trabka, and
E Telesz, and
T Zelazny
October 2010,
Circulation. Cardiovascular interventions,
A Dembinska-Kiec, and
A Zmuda, and
L Grodzinska, and
K Bieron, and
M Basista, and
A Kedzior, and
E Kostka-Trabka, and
E Telesz, and
T Zelazny
April 1984,
Prostaglandins, leukotrienes, and medicine,
A Dembinska-Kiec, and
A Zmuda, and
L Grodzinska, and
K Bieron, and
M Basista, and
A Kedzior, and
E Kostka-Trabka, and
E Telesz, and
T Zelazny
July 1994,
Prostaglandins,
A Dembinska-Kiec, and
A Zmuda, and
L Grodzinska, and
K Bieron, and
M Basista, and
A Kedzior, and
E Kostka-Trabka, and
E Telesz, and
T Zelazny
February 1980,
Prostaglandins,
A Dembinska-Kiec, and
A Zmuda, and
L Grodzinska, and
K Bieron, and
M Basista, and
A Kedzior, and
E Kostka-Trabka, and
E Telesz, and
T Zelazny
May 1981,
Experientia,
A Dembinska-Kiec, and
A Zmuda, and
L Grodzinska, and
K Bieron, and
M Basista, and
A Kedzior, and
E Kostka-Trabka, and
E Telesz, and
T Zelazny
September 1984,
British journal of clinical pharmacology,
A Dembinska-Kiec, and
A Zmuda, and
L Grodzinska, and
K Bieron, and
M Basista, and
A Kedzior, and
E Kostka-Trabka, and
E Telesz, and
T Zelazny
December 1985,
Circulation,
A Dembinska-Kiec, and
A Zmuda, and
L Grodzinska, and
K Bieron, and
M Basista, and
A Kedzior, and
E Kostka-Trabka, and
E Telesz, and
T Zelazny
December 1987,
Thrombosis research,
