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Most ophthalmic preparations contain preservatives. Some are toxic to healthy corneal epithelium or retard healing of corneas from which part or all of the epithelium has been removed leaving an intact basement membrane. In this paper, the effect of commonly used concentrations of benzalkonium chloride (BAC), thimerosal, and ethylenediaminetetracetic acid (EDTA) upon the healing of rabbit corneas after partial lamellar keratectomy is investigated. This model has not been used previously for a study of preservative toxicity. Thimerosal (0.004%), BAC (0.01%), or EDTA (0.1%) applied four times per day had no significant effect on the corneal healing or epithelial migration rates. A slight retardation occurred when BAC (0.01%) and EDTA (0.1%) were used together, while healing failed to occur as long as benzalkonium chloride (0.02%) was administered.
H B Collin, and
B E Grabsch
November 1988,
American journal of optometry and physiological optics,
H B Collin, and
B E Grabsch
January 1992,
Lens and eye toxicity research,
H B Collin, and
B E Grabsch
January 1989,
Lens and eye toxicity research,
H B Collin, and
B E Grabsch
February 1982,
Toxicology and applied pharmacology,
H B Collin, and
B E Grabsch
April 2005,
Cornea,
H B Collin, and
B E Grabsch
April 1998,
Journal of refractive surgery (Thorofare, N.J. : 1995),
H B Collin, and
B E Grabsch
July 1998,
Cornea,
H B Collin, and
B E Grabsch
August 1973,
American journal of ophthalmology,
H B Collin, and
B E Grabsch
April 1976,
Investigative ophthalmology,
H B Collin, and
B E Grabsch
October 2005,
Journal of cataract and refractive surgery,
