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1 The effects of sodium valproate on the performance of a series of psychological tests and mood was studied. 2 Ten healthy male volunteers received sodium valproate and placebo, each for a period of 2 weeks, in a double-blind cross-over design. Dosage of sodium valproate was increased to 800 mg/day in the first week and to 1 g/day in the second week of treatment. 3 Psychological testing took place on three occasions, before and on completion of each of the two treatment periods. 4 The few significant differences between drug and placebo conditions indicated impairment on sodium valproate. 5 The findings are discussed in relation to those from a similarly designed study of the anticonvulsant phenytoin. Implications for epilepsy are also considered.
P J Thompson, and
M R Trimble
January 1993,
Indian journal of psychiatry,
P J Thompson, and
M R Trimble
January 1998,
Indian journal of experimental biology,
P J Thompson, and
M R Trimble
April 1993,
Clinical EEG (electroencephalography),
P J Thompson, and
M R Trimble
December 1989,
Neurology,
P J Thompson, and
M R Trimble
July 1996,
Journal of child neurology,
P J Thompson, and
M R Trimble
April 1992,
Indian journal of physiology and pharmacology,
P J Thompson, and
M R Trimble
February 2009,
Tijdschrift voor gerontologie en geriatrie,
P J Thompson, and
M R Trimble
December 2017,
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie,
P J Thompson, and
M R Trimble
July 2005,
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology,
