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In five of six epileptic children who were taking 18 to 49 mg/kg/day valproic acid (VPA), the steady-state serum free fractions of VPA rose from 12% to 43% when antipyretic doses of aspirin were also taken. Mean total VPA half-life (t1/2) rose from 10.4 +/- 2.7 to 12.9 +/- 1.8 hr and mean free VPA t1/2 rose from 6.7 +/- to 2.1 to 8.9 +2- 3.0 hr when salicylate was present in the serum. The in vitro albumin binding association constant (ka) for VPA was decreased by salicylate, but the in vivo ka value was not affected. The 12-hr (trough) concentrations of both free and total VPA were higher in the presence of serum salicylate in five of six patients. Renal excretion of unchanged VPA decreased in five of six patients, but the VPA carboxyl conjugate metabolite-excretion patterns were not consistently affected. Salicylate appeared to displace VPA from serum albumin in vivo, but the increased VPA t1/2 and changes in VPA elimination patterns suggest that serum salicylate also altered VPA metabolism.
J M Orr, and
F S Abbott, and
K Farrell, and
S Ferguson, and
I Sheppard, and
W Godolphin
December 1980,
Clinical pharmacology and therapeutics,
J M Orr, and
F S Abbott, and
K Farrell, and
S Ferguson, and
I Sheppard, and
W Godolphin
December 1982,
Taiwan yi xue hui za zhi. Journal of the Formosan Medical Association,
J M Orr, and
F S Abbott, and
K Farrell, and
S Ferguson, and
I Sheppard, and
W Godolphin
March 1982,
The Journal of pediatrics,
J M Orr, and
F S Abbott, and
K Farrell, and
S Ferguson, and
I Sheppard, and
W Godolphin
January 1984,
European journal of drug metabolism and pharmacokinetics,
J M Orr, and
F S Abbott, and
K Farrell, and
S Ferguson, and
I Sheppard, and
W Godolphin
December 1978,
British journal of clinical pharmacology,
J M Orr, and
F S Abbott, and
K Farrell, and
S Ferguson, and
I Sheppard, and
W Godolphin
November 1978,
British journal of clinical pharmacology,
J M Orr, and
F S Abbott, and
K Farrell, and
S Ferguson, and
I Sheppard, and
W Godolphin
January 1997,
Biological trace element research,
J M Orr, and
F S Abbott, and
K Farrell, and
S Ferguson, and
I Sheppard, and
W Godolphin
January 1982,
Therapeutic drug monitoring,
J M Orr, and
F S Abbott, and
K Farrell, and
S Ferguson, and
I Sheppard, and
W Godolphin
March 2017,
The Kaohsiung journal of medical sciences,
J M Orr, and
F S Abbott, and
K Farrell, and
S Ferguson, and
I Sheppard, and
W Godolphin
February 1998,
Biological & pharmaceutical bulletin,
