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5 patients treated with perhexiline maleate, 200-400 mg/day for at least 6 months, exhibited evidence of hepatitis. The picture was very similar to acute alcoholic hepatitis, clinically, biologically and histologically with presence of necrosis, Mallory's hyaline, polynuclear infiltration and to a lesser degree, steatosis. Association with peripheral neuropathy, hypoglycemia, and renal failure appears strikingly frequently. The evolution was severe since 3 patients died within 6 months, even after treatment withdrawal. Further studies are to be done to understand the mechanisms of hepatic and neurologic toxicity, and to measure the hazards of this drug. These studies could bring a new insight to alcohol toxicity.
P Paliard, and
D Vitrey, and
G Fournier, and
J Belhadjali, and
L Patricot, and
F Berger
August 1991,
Hepato-gastroenterology,
P Paliard, and
D Vitrey, and
G Fournier, and
J Belhadjali, and
L Patricot, and
F Berger
January 1978,
Coeur et medecine interne,
P Paliard, and
D Vitrey, and
G Fournier, and
J Belhadjali, and
L Patricot, and
F Berger
January 1982,
Acta gastro-enterologica Belgica,
P Paliard, and
D Vitrey, and
G Fournier, and
J Belhadjali, and
L Patricot, and
F Berger
January 1979,
Gastroenterology,
P Paliard, and
D Vitrey, and
G Fournier, and
J Belhadjali, and
L Patricot, and
F Berger
April 1983,
Pathology,
P Paliard, and
D Vitrey, and
G Fournier, and
J Belhadjali, and
L Patricot, and
F Berger
July 1979,
The Medical journal of Australia,
P Paliard, and
D Vitrey, and
G Fournier, and
J Belhadjali, and
L Patricot, and
F Berger
November 1981,
The Medical journal of Australia,
P Paliard, and
D Vitrey, and
G Fournier, and
J Belhadjali, and
L Patricot, and
F Berger
January 1981,
Acta gastro-enterologica Belgica,
P Paliard, and
D Vitrey, and
G Fournier, and
J Belhadjali, and
L Patricot, and
F Berger
July 1982,
The Medical journal of Australia,
P Paliard, and
D Vitrey, and
G Fournier, and
J Belhadjali, and
L Patricot, and
F Berger
April 1976,
La Nouvelle presse medicale,
