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The effects of acetazolamide administration on arterial blood acid-base equilibrium and electrolyte concentrations were evaluated in 13 clinical patients and in a 4-week experiment in 6 conditioned mixed-breed dogs. Findings included persistent acidemia characterized by hyperchloremic metabolic acidosis, elevated partial pressure of oxygen, and mild depletion of potassium. Changes in the partial pressure of carbon dioxide were variable, and there was no change in plasma sodium concentration or osmolality. Measured disturbances were apparent within 12 hours of the commencement of acetazolamide administration, peaked at between 1.5 and 5.0 days, and thereafter stabilized. Abnormalities were restored to normal within 1.5 days following termination of drug administration.
S C Haskins, and
R J Munger, and
M G Helphrey, and
B A Gilroy, and
J D Patz, and
M D Steele, and
W Shapiro
May 1982,
Journal of the American Veterinary Medical Association,
S C Haskins, and
R J Munger, and
M G Helphrey, and
B A Gilroy, and
J D Patz, and
M D Steele, and
W Shapiro
August 2009,
Research in veterinary science,
S C Haskins, and
R J Munger, and
M G Helphrey, and
B A Gilroy, and
J D Patz, and
M D Steele, and
W Shapiro
January 2014,
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S C Haskins, and
R J Munger, and
M G Helphrey, and
B A Gilroy, and
J D Patz, and
M D Steele, and
W Shapiro
October 2000,
Canadian journal of veterinary research = Revue canadienne de recherche veterinaire,
S C Haskins, and
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M G Helphrey, and
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J D Patz, and
M D Steele, and
W Shapiro
March 1966,
Minnesota medicine,
S C Haskins, and
R J Munger, and
M G Helphrey, and
B A Gilroy, and
J D Patz, and
M D Steele, and
W Shapiro
January 1986,
Acta veterinaria Hungarica,
S C Haskins, and
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M G Helphrey, and
B A Gilroy, and
J D Patz, and
M D Steele, and
W Shapiro
January 1962,
Scandinavian journal of clinical and laboratory investigation,
S C Haskins, and
R J Munger, and
M G Helphrey, and
B A Gilroy, and
J D Patz, and
M D Steele, and
W Shapiro
August 1990,
Veterinarni medicina,
S C Haskins, and
R J Munger, and
M G Helphrey, and
B A Gilroy, and
J D Patz, and
M D Steele, and
W Shapiro
January 1972,
Progress in clinical pathology,
S C Haskins, and
R J Munger, and
M G Helphrey, and
B A Gilroy, and
J D Patz, and
M D Steele, and
W Shapiro
August 1987,
Respiration physiology,
