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A model of minimal brain dysfunction (MBD) in rats based on injection of 6-OH-dopamine (DA) intracisternally on the 5th day of life has been described previously. Since 6-OH-DA pretreatment has been reported in adult rats to lead to a compensatory rise in DA receptor number, we measured DA receptor number in animals treated with 6-OH-DA on the 5th day of life, after completion of behavioral observations on days 17, 20 and 23 of life. Rats pretreated with 6-OH-DA at day 5 were found, on sacrifice on day 23, to have a mean increase of about 20% in caudate spiperone binding. There was a significant correlation between spiperone binding and gross activity in 6-OH-DA-treated animals but not in untreated animals. Since the significant correlation between receptor number and gross activity is negative and DA receptor stimulators are known to increase activity, it appears that receptor number changes are not directly related to hyperactivity.
J Eisenberg, and
E Brecher-Fride, and
R Weizman, and
R P Ebstein, and
R H Belmaker
October 1976,
Science (New York, N.Y.),
J Eisenberg, and
E Brecher-Fride, and
R Weizman, and
R P Ebstein, and
R H Belmaker
October 1976,
Science (New York, N.Y.),
J Eisenberg, and
E Brecher-Fride, and
R Weizman, and
R P Ebstein, and
R H Belmaker
October 1976,
Science (New York, N.Y.),
J Eisenberg, and
E Brecher-Fride, and
R Weizman, and
R P Ebstein, and
R H Belmaker
January 1976,
Science (New York, N.Y.),
J Eisenberg, and
E Brecher-Fride, and
R Weizman, and
R P Ebstein, and
R H Belmaker
February 1980,
Psychopharmacology,
J Eisenberg, and
E Brecher-Fride, and
R Weizman, and
R P Ebstein, and
R H Belmaker
February 1973,
Annals of the New York Academy of Sciences,
J Eisenberg, and
E Brecher-Fride, and
R Weizman, and
R P Ebstein, and
R H Belmaker
April 1976,
Diseases of the nervous system,
J Eisenberg, and
E Brecher-Fride, and
R Weizman, and
R P Ebstein, and
R H Belmaker
June 1979,
Brain research,
J Eisenberg, and
E Brecher-Fride, and
R Weizman, and
R P Ebstein, and
R H Belmaker
January 1979,
Communications in psychopharmacology,
J Eisenberg, and
E Brecher-Fride, and
R Weizman, and
R P Ebstein, and
R H Belmaker
September 1973,
Fortschritte der Medizin,
