Biomaterial Database

Ultrasonic potentiation of the sporicidal activity of glutaraldehyde. 1982

D K Warfield, and S Q Bryington

Laboratory test data showed a 4.8-fold increase in the sporicidal activity of glutaraldehyde with the incorporation of ultrasound. Projected times required for 100 percent killed of a 20,000 hydrated spore inoculant were reduced from 211 minutes to 44 minutes. Clinical exposure time intervals necessitated a 31/2-hour glutaraldehyde immersion versus a 30-minute cavitated glutaraldehyde chemosterilization to ensure a 100 percent kill. The feasibility of reducing the ADA-required 10-hour soak in glutaraldehyde to ensure sterility with the incorporation of ultrasonic baths is supported by these data. Tests performed also showed that the airborne contamination from an open tank method is minimal. No spores were retrieved from vapor collected by passive vacuum during cavitation of inoculated glutaraldehyde.

UI	MeSH Term	Description	Entries
D003762	Dental Instruments	Hand-held tools or implements especially used by dental professionals for the performance of clinical tasks.	Instrument, Dental,Dental Instrument,Instruments, Dental
D004357	Drug Synergism	The action of a drug in promoting or enhancing the effectiveness of another drug.	Drug Potentiation,Drug Augmentation,Augmentation, Drug,Augmentations, Drug,Drug Augmentations,Drug Potentiations,Drug Synergisms,Potentiation, Drug,Potentiations, Drug,Synergism, Drug,Synergisms, Drug
D005976	Glutaral	One of the protein CROSS-LINKING REAGENTS that is used as a disinfectant for sterilization of heat-sensitive equipment and as a laboratory reagent, especially as a fixative.	Glutaraldehyde,Cidex,Diswart,Gludesin,Glutardialdehyde,Glutarol,Korsolex,Novaruca,Sekumatic,Sonacide,Sporicidin
D000447	Aldehydes	Organic compounds containing a carbonyl group in the form -CHO.	Aldehyde
D001411	Geobacillus stearothermophilus	A species of GRAM-POSITIVE ENDOSPORE-FORMING BACTERIA in the family BACILLACEAE, found in soil, hot springs, Arctic waters, ocean sediments, and spoiled food products.	Bacillus stearothermophilus,Bacillus thermoliquefaciens
D013171	Spores, Bacterial	Heat and stain resistant, metabolically inactive bodies formed within the vegetative cells of bacteria of the genera Bacillus and Clostridium.	Bacterial Spores,Bacterial Spore,Spore, Bacterial
D013242	Sterilization	The destroying of all forms of life, especially microorganisms, by heat, chemical, or other means.
D013997	Time Factors	Elements of limited time intervals, contributing to particular results or situations.	Time Series,Factor, Time,Time Factor
D014465	Ultrasonics	A subfield of acoustics dealing in the radio frequency range higher than acoustic SOUND waves (approximately above 20 kilohertz). Ultrasonic radiation is used therapeutically (DIATHERMY and ULTRASONIC THERAPY) to generate HEAT and to selectively destroy tissues. It is also used in diagnostics, for example, ULTRASONOGRAPHY; ECHOENCEPHALOGRAPHY; and ECHOCARDIOGRAPHY, to visually display echoes received from irradiated tissues.	Ultrasonic