-transparent.png){kind=logo}
The effect of once-daily dosage of the two most widely prescribed cardioselective beta-adrenoceptor antagonists used to treat hypertension--namely, atenolol and metoprolol--was studied in nine carefully selected hypertensive outpatients. Each patient received atenolol 50 mg/day, atenolol 100 mg/day, metoprolol 100 mg/day, and metoprolol 200 mg/day in a sustained-release formulation (as Lopresor SR) according to a randomised sequence. After three weeks' treatment with each drug given once daily comparisons of the treatments 24 hours after dosing showed no important differences between 50 and 100 mg atenolol/day. Metoprolol, as both the standard and the slow-release formulations, had some limitations in controlling systolic blood pressure and heart rate. These results suggest that the recommendations for the treatment of hypertension with these cardioselective beta-adrenoceptor antagonists should be reconsidered since doses smaller than those recommended are almost as effective and much cheaper.
A K Scott, and
J W Rigby, and
J Webster, and
G M Hawksworth, and
J C Petrie, and
H G Lovell
October 1977,
British journal of clinical pharmacology,
A K Scott, and
J W Rigby, and
J Webster, and
G M Hawksworth, and
J C Petrie, and
H G Lovell
October 1981,
Postgraduate medical journal,
A K Scott, and
J W Rigby, and
J Webster, and
G M Hawksworth, and
J C Petrie, and
H G Lovell
June 1983,
British journal of clinical pharmacology,
A K Scott, and
J W Rigby, and
J Webster, and
G M Hawksworth, and
J C Petrie, and
H G Lovell
April 1979,
Clinical pharmacology and therapeutics,
A K Scott, and
J W Rigby, and
J Webster, and
G M Hawksworth, and
J C Petrie, and
H G Lovell
June 1976,
British medical journal,
A K Scott, and
J W Rigby, and
J Webster, and
G M Hawksworth, and
J C Petrie, and
H G Lovell
February 1979,
Annals of clinical research,
A K Scott, and
J W Rigby, and
J Webster, and
G M Hawksworth, and
J C Petrie, and
H G Lovell
December 1989,
Journal of hypertension. Supplement : official journal of the International Society of Hypertension,
A K Scott, and
J W Rigby, and
J Webster, and
G M Hawksworth, and
J C Petrie, and
H G Lovell
November 1977,
Postgraduate medical journal,
A K Scott, and
J W Rigby, and
J Webster, and
G M Hawksworth, and
J C Petrie, and
H G Lovell
March 1982,
The Practitioner,
A K Scott, and
J W Rigby, and
J Webster, and
G M Hawksworth, and
J C Petrie, and
H G Lovell
January 1977,
Proceedings of the Royal Society of Medicine,
