A search for an enriched source of polymeric IgA in human thoracic duct lymph, portal vein blood and aortic blood. 1982

W R Brown, and P D Smith, and E Lee, and R T McCalmon, and H Nagura

Because human bile contains a lot of secretory IgA, it has been suspected that the human liver, like rat liver, transfers polymeric IgA from plasma to bile. Hence, a rich source of polymeric IgA might enter the general circulation of man. We examined human thoracic duct lymph, portal vein blood and aortic blood for content and molecular size of IgA. None of the fluids was found to have either a higher total concentration of IgA or a higher proportion of polymeric IgA than that found in peripheral venous blood. It is possible that hepatic clearance of plasma IgA does not occur in man to the extent that it does in the rat, and a relatively larger proportion of human biliary IgA might originate from synthesis in hepatobiliary tissues.

UI MeSH Term Description Entries
D007070 Immunoglobulin A Represents 15-20% of the human serum immunoglobulins, mostly as the 4-chain polymer in humans or dimer in other mammals. Secretory IgA (IMMUNOGLOBULIN A, SECRETORY) is the main immunoglobulin in secretions. IgA,IgA Antibody,IgA1,IgA2,Antibody, IgA
D007074 Immunoglobulin G The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B. Gamma Globulin, 7S,IgG,IgG Antibody,Allerglobuline,IgG(T),IgG1,IgG2,IgG2A,IgG2B,IgG3,IgG4,Immunoglobulin GT,Polyglobin,7S Gamma Globulin,Antibody, IgG,GT, Immunoglobulin
D007075 Immunoglobulin M A class of immunoglobulin bearing mu chains (IMMUNOGLOBULIN MU-CHAINS). IgM can fix COMPLEMENT. The name comes from its high molecular weight and originally was called a macroglobulin. Gamma Globulin, 19S,IgM,IgM Antibody,IgM1,IgM2,19S Gamma Globulin,Antibody, IgM
D008196 Lymph The interstitial fluid that is in the LYMPHATIC SYSTEM. Lymphs
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D011169 Portal Vein A short thick vein formed by union of the superior mesenteric vein and the splenic vein. Portal Veins,Vein, Portal,Veins, Portal
D001769 Blood The body fluid that circulates in the vascular system (BLOOD VESSELS). Whole blood includes PLASMA and BLOOD CELLS.
D005260 Female Females
D005779 Immunodiffusion Technique involving the diffusion of antigen or antibody through a semisolid medium, usually agar or agarose gel, with the result being a precipitin reaction. Gel Diffusion Tests,Diffusion Test, Gel,Diffusion Tests, Gel,Gel Diffusion Test,Immunodiffusions,Test, Gel Diffusion,Tests, Gel Diffusion

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