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Non-glucoregulatory hormones (T4, T3, rT3, TSH and testosterone) were studied by radioimmunoassay in juvenile-type diabetics in moderate control and in ketosis due to insulin withdrawal and in age matched "normals" during a mild prolonged exercise test. The basal serum hormone levels revealed the following findings: Serum testosterone was markedly lower in diabetics than in normals ( 177 +/- 24 resp. 618 +/- 52 ng/dl). This is in contrast to other studies, but it may reflect decreased testicular function due to an early, clinically not apparent atherosclerotic disease. Serum T3 was significantly lower in diabetics than in normals (110 +/- 16 resp. 145 +/- 19), suggesting an early "low T3-syndrome" in juvenile-type diabetics. However, increased serum rT3 levels were not observed, and serum T4 and TSH were normal. Mild prolonged exercise had no major effects on these nonglucoregulatory hormones. In juvenile-type diabetics the degree of metabolic control had no influence on the response of the mentioned hormones. However, an increased cortisol/testosterone ratio in ketotic diabetics in the basal state with a further increase during exercise was demonstrated, indicating an aggravation of the catabolic state in these patients during exercise.
P Berchtold, and
M Berger, and
H J Cüppers, and
J Herrmann, and
E Nieschlag, and
K Rudorff, and
H Zimmermann, and
H L Krüskemper
January 1981,
Acta medica Austriaca,
P Berchtold, and
M Berger, and
H J Cüppers, and
J Herrmann, and
E Nieschlag, and
K Rudorff, and
H Zimmermann, and
H L Krüskemper
January 1982,
European journal of applied physiology and occupational physiology,
P Berchtold, and
M Berger, and
H J Cüppers, and
J Herrmann, and
E Nieschlag, and
K Rudorff, and
H Zimmermann, and
H L Krüskemper
April 1983,
Bollettino della Societa italiana di biologia sperimentale,
P Berchtold, and
M Berger, and
H J Cüppers, and
J Herrmann, and
E Nieschlag, and
K Rudorff, and
H Zimmermann, and
H L Krüskemper
July 1978,
Acta endocrinologica,
P Berchtold, and
M Berger, and
H J Cüppers, and
J Herrmann, and
E Nieschlag, and
K Rudorff, and
H Zimmermann, and
H L Krüskemper
April 1983,
Bollettino della Societa italiana di biologia sperimentale,
P Berchtold, and
M Berger, and
H J Cüppers, and
J Herrmann, and
E Nieschlag, and
K Rudorff, and
H Zimmermann, and
H L Krüskemper
January 1984,
Hormone research,
P Berchtold, and
M Berger, and
H J Cüppers, and
J Herrmann, and
E Nieschlag, and
K Rudorff, and
H Zimmermann, and
H L Krüskemper
March 1986,
Quaderni Sclavo di diagnostica clinica e di laboratorio,
P Berchtold, and
M Berger, and
H J Cüppers, and
J Herrmann, and
E Nieschlag, and
K Rudorff, and
H Zimmermann, and
H L Krüskemper
January 1980,
Endocrinologie,
P Berchtold, and
M Berger, and
H J Cüppers, and
J Herrmann, and
E Nieschlag, and
K Rudorff, and
H Zimmermann, and
H L Krüskemper
January 1980,
Journal of endocrinological investigation,
P Berchtold, and
M Berger, and
H J Cüppers, and
J Herrmann, and
E Nieschlag, and
K Rudorff, and
H Zimmermann, and
H L Krüskemper
April 1985,
La Clinica terapeutica,
