-transparent.png){kind=logo}
The steroids 7 alpha,17 beta-dihydroxy-5 alpha-androstan-3-one (7 alpha-hydroxy-Dht), 5 alpha-androstan-3 alpha,7 alpha,17 beta-triol (7 alpha-hydroxy-3 alpha-A'DIOL) and 5 alpha-androstane-3 beta,7 alpha,17 beta-triol (7 alpha-hydroxy-3 beta-A'DIOL) have been synthetized from 7 alpha,17 beta-dihydroxy-4-androsten-3-one (7 alpha-hydroxy-testosterone). The effect of administering 7 alpha-hydroxy-Dht, 7 alpha-hydroxy-3 alpha-A'DIOL or 7 alpha-hydroxy-3 beta-A'DIOL on serum levels of LH, FSH and on ventral prostate and seminal vesicle weight were investigated in gonadectomized adult male rats. Each steroid was administered for seven days in a dose of 300 micrograms per day. No suppression of serum LH or FSH levels was recorded following injections of these 7 alpha-hydroxylated steroids to castrated rats, compared to castrated control rats receiving vehicle only. Administration of 7 alpha-hydroxy-Dht or 7 alpha-hydroxy-3 alpha-A'DIOL to castrated mature rats could maintain ventral prostate and seminal vesicle weights above that of castrated control rats. Administration of 7 alpha-hydroxy-3 beta-A'DIOL to castrated mature rats resulted in ventral prostate weights slightly above castrate control levels, while seminal vesicle weight in such rats were in the same range as castrated control rats. Intraperitoneal administration of testosterone or of 5 alpha-androstane-3 beta,17 beta-diol (3 beta-A'DIOL) to castrated rats maintained activity of the androgen dependent isoenzyme of acid phosphatase in the ventral prostate; 7 alpha-hydroxy-testosterone or 7 alpha-hydroxy-3 beta-A'DIOL showed, however, no effect on this enzymic activity.
A Sunde, and
K Aareskjold, and
E Haug, and
K B Eik-Nes
July 1982,
Journal of steroid biochemistry,
A Sunde, and
K Aareskjold, and
E Haug, and
K B Eik-Nes
December 1983,
Steroids,
A Sunde, and
K Aareskjold, and
E Haug, and
K B Eik-Nes
March 1980,
Steroids,
A Sunde, and
K Aareskjold, and
E Haug, and
K B Eik-Nes
April 1984,
Steroids,
A Sunde, and
K Aareskjold, and
E Haug, and
K B Eik-Nes
January 1980,
Journal of steroid biochemistry,
A Sunde, and
K Aareskjold, and
E Haug, and
K B Eik-Nes
August 1979,
Biochimica et biophysica acta,
A Sunde, and
K Aareskjold, and
E Haug, and
K B Eik-Nes
February 1980,
Steroids,
A Sunde, and
K Aareskjold, and
E Haug, and
K B Eik-Nes
January 1979,
Comptes rendus des seances de l'Academie des sciences. Serie D, Sciences naturelles,
A Sunde, and
K Aareskjold, and
E Haug, and
K B Eik-Nes
January 1986,
Steroids,
A Sunde, and
K Aareskjold, and
E Haug, and
K B Eik-Nes
October 1964,
Chemical & pharmaceutical bulletin,
