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Dual isohypercapnic studies on the time course of depression following intravenous diazepam permit detailed analysis of changes in the ventilatory response to carbon dioxide. The mean slope of the CO2 response curves of eight healthy volunteers dropped from 2.38 to 1.21 1 . min-1 . mmHg-1 ( P less than 0.05) within three minutes after injection of diazepam 0.4 mg/kg. Twenty-five minutes after injection, the slope was only 1.49 1 . min-1 . mmHg-1, still significantly lower than control (P less than 0.05). At 30 min, the slope has increased to 1.73 1 . min-1 . mmHg-1 and was no longer different from control at the 0.05 level of significance. There was also a significant correlation between the slope of the CO2 response curve and level of consciousness (r = 0. 81). There was little or no displacement of the response curve at any selected ventilation except as accounted for by the slope change. The authors conclude that ventilatory depression resulting from intravenous diazepam begins within one minute and lasts at least 25 min after injection.
J B Gross, and
L Smith, and
T C Smith
September 1986,
Anesthesiology,
J B Gross, and
L Smith, and
T C Smith
May 1996,
British journal of anaesthesia,
J B Gross, and
L Smith, and
T C Smith
June 1991,
Anesthesia and analgesia,
J B Gross, and
L Smith, and
T C Smith
August 1987,
Anesthesia and analgesia,
J B Gross, and
L Smith, and
T C Smith
January 1976,
Clinical science and molecular medicine,
J B Gross, and
L Smith, and
T C Smith
September 1964,
Journal of applied physiology,
J B Gross, and
L Smith, and
T C Smith
March 1978,
Lancet (London, England),
J B Gross, and
L Smith, and
T C Smith
July 1976,
Chest,
J B Gross, and
L Smith, and
T C Smith
April 1987,
Anesthesiology,
J B Gross, and
L Smith, and
T C Smith
October 1970,
The American review of respiratory disease,
